TABLE 2

Characteristics and clinical outcome of patients with CNS infections and positive for CyCV-VN by PCR

Group
and
patient
(n)a
Other
confirmed
diagnosisb
Sample
date
No. (%) of males
in group or sex
of patientc,d
Age
(yr)d
Length of
hospital
stay
(days)d
Illness
day  
No. of patients withd:CSF white
blood cell
count
% of
lympho-
cytes
in CSF
CSF/blood
glucose
ratio
Out-
comef
Sequelae
at
discharge
FeverConvul-
sions
Neck
stiff-
ness
Limb
weak-
ness
Head-
ache
Vom-
iting
GCS
scoree
Group 1
(12)
9
(75)
19.5
(<1–50)
8
(2–41)
5
(2–20)
11
(92)
4
(33)
7
(58)
2
(18)
6
(86)
8
(89)
40
(1–464)
 1NoneJan. 5, 2004F<175YNNYNANA2 (BCS)10.881None
 2NoneJun. 8, 2004M<187YNNNNANA3 (BCS)30.531None
 3NoneFeb. 7, 2004M1283YNNNNANA626900.961None
 4NoneOct. 18, 1999M2757YNYNANAY1554680.551None
 5NoneJun. 12, 2008M3122YYNNYY15100.543Unknown
 6NoneNov. 25, 2009F<292YYNNNAY5 (BCS)10600.561Unknown
 7NoneNov. 29, 2008M204120YYYYYY7160300.731Unknown
 8NoneSep. 4, 2009M15159YNYNYY1578200.621Unknown
 9NoneSep. 7, 2009F50157YNYNYY15105220.441Unknown
 10NoneNov. 18, 2009M1955YYYNYN1114360.551Unknown
 11NoneMar. 31, 2008M4335NNYNYY978200.573Unknown
 12NoneApr. 16, 2008M24174YNYNNY15464200.511Unknown
Group 2
(4)
3
(75)
14
(2–19)
14
(4–38)
5.5
(2–7)
2
(50)
3
(100)
2
(50)
1
(25)
2
(100)
2
(100)
50 (0–110)
 1JEVJan. 30 2004M242NNNNNANA1300.981None
 2JEVAug. 12 2004M1155YNYNNANA1122650.811None
 3DENVOct. 24 2008M19387NNAYYYY979210.411Unknown
 4JEVMay 05 2008F17236YNNNYY15110250.711Unknown
Group 3
(7)
6
(85)
5
(<1–61)
19
(1–34)
2
(1–3)
6
(85)
2
(28)
5
(71)
1
(14)
4
(100)
4
(57)
1,439
(2–9,160)
 1S. suisAug. 31, 2008M29211NNYNYY153,5000.041Unknown
 2S. pneumoniaeNov. 17, 2008M25162YNYNYY155,513200.231Unknown
 3H. influenzaeJan. 20, 2009M<1191YNYNNAN5 (BCS)9,16090.361Unknown
 4S. pneumoniaeJan. 27, 2009M511YYNYYY830110.182
 5S. suisMar. 16, 2009F61343YNYNNAN111,439280.191Unknown
 6S. pneumoniaeApr. 17, 2009M242YYNNNAN0 (BCS)20.651Unknown
 7S. pneumoniaeDec. 23, 2009M3202YNYNyY1180330.951Unknown
Group 4
(5)
1
(20)
32
(29–68)
4
(2–10)
5
(3–7)
4
(80)
04
(80)
0NANA296
(100–950)
 1187M. tuberculosisAug. 4, 2009F3047YNYNNANA13296NA0.183Unknown
 1847NoneFeb. 16, 2009M32103YNYNNANA15100200.131Unknown
 1854NoneJul. 24, 2009F2923YNNNNANA15603200.341Unknown
 2117M. tuberculosisFeb. 9, 2010F55NA7NUnknownYNNANA795060NA3Unknown
 2460NoneNov. 13, 2008F68NA5YNYNNANA15296NA0.723Unknown
  • a Group 1, patients with CNS infections of unknown etiology; group 2, patients with laboratory-confirmed CNS infections; group 3, bacterial meningitis patients; group 4, PCR confirmed/clinically suspected tuberculosis meningitis patients. Names of provinces from which the patients were originated are intentionally not shown; patients 5 and 6 were the index cases in whose samples the CyCV-like sequence was detected by VIDISCA-454.

  • b For M. tuberculosis, denominators may vary. JEV, Japanese encephalitis virus; DENV, dengue virus.

  • c M, male; F, female.

  • d Data are numbers (percentages) of patients; continuous variables are presented as medians (ranges). NA, not available; Y, yes; N, no.

  • e Scores are on the Glasgow coma scale (GCS) unless the Blantyre coma scale (BCS) is indicated.

  • f 1, recovery; 2, death; 3, unknown.