TABLE 4 

Effect size of MC, measured as the change in absolute abundances of coronal sulcus bacteria that significantly decreased (i.e., “negative responders”) or increased (i.e., “positive responders”) post-MC, adjusted by changes in abundance among uncircumcised men over timea

Category and bacterial groupbIndicator value (FDR-adjusted P value)MC effect size [mean (90% CI)]
Negative responders to MC
Prevotella spp.***0.18 (0.06)−25,327 (−48,812 to −3,988)
Porphyromonas spp.***0.27 (<0.01)−14,232 (−28,698 to −2,358)
 Unclassified Clostridiales spp.*0.24 (0.01)−10,087 (−32,278 to 12,802)
 Unclassified Clostridiales family XI*0.22 (0.03)−3,299 (−8,715 to 647)
Murdochiella spp.*0.30 (<0.01)−3,207 (−10,314 to 5,319)
Peptoniphilus spp.*0.29 (<0.01)−1,349 (−8,121 to 5,388)
Finegoldia spp.***0.24 (0.07)−1,343 (−2,385 to −438)
Anaerococcus spp.**0.27 (0.03)−1,284 (−2,292 to −337)
Peptostreptococcus spp.***0.21 (<0.01)−1,157 (−2,415 to −188)
Mobiluncus spp.*0.16 (0.02)−568 (−1,480 to 290)
Actinomyces spp.0.20 (0.01)−286 (−780 to 13)
Saccharofermentans spp.0.16 (0.03)−281 (−1,545 to 1,032)
Negativicoccus spp.*0.28 (<0.01)−244 (−785 to 321)
Sutterella spp.*0.13 (0.01)−110 (−258 to 12)
Howardella spp.0.14 (0.01)−44 (−175 to 75)
Olsenella spp.*0.17 (0.01)−37 (−270 to 171)
Ralstonia spp.0.14 (0.01)0 (0 to 1)
Dialister spp.*0.24 (<0.01)1,434 (−1,259 to 4,618)
Positive responders to MC
Rothia spp.0.12 (<0.01)1 (0 to 2)
Roseomonas spp.0.11 (0.04)1 (0 to 2)
Kocuria spp.***0.32 (<0.01)8 (5 to 11)
Brevibacterium***0.30 (<0.01)13 (5 to 22)
Eremococcus**0.26 (0.06)45 (8 to 94)
Bifidobacterium0.16 (<0.01)101 (−7 to 243)
Helcococcus***0.21 (0.02)161 (22 to 345)
Staphylococcus***0.56 (<0.01)259 (168 to 353)
Corynebacterium***0.50 (<0.01)2,857 (1,440 to 4,722)
  • a  The negative and positive responders to MC were identified using indicator analysis, which also produced the indicator values.

  • b  *, significant change in prevalence only; **, significant change in absolute abundance (i.e., load) only; ***, significant change in both prevalence and absolute abundance.