TABLE 1 

rpoB mutations in rifampin-resistant mutants obtained through a fluctuation test and intragenic compensatory mutations in compensated mutants evolved through a selection experiment

Point mutation(s)Amino acid substitution(s)
Original resistance mutation
    A1553TQ518L
    A1553GQ518R
    A1562GD521G
    G1561AD521N
    A1592TH531L
    A1592GH531R
    C1591TH531Y
    C1607TS536F
    C1736TS579F
Original + compensatory mutation
    C1591T + A1592GH531C
    A1553G + G1584TQ518R + E528D
    C1591T + A1718GH531Y + N573S