TABLE 2 

Genetic characteristics of LRCoNS (n = 28)

CaseSpeciesSTcfrcfr
plasmid
% of 23S rRNA copies harboring SNVL3
mutation(s)
L4
mutation
Linezolid
MIC
(µg/ml)a
G2576UC2534UG2447UU2504A
1S. epidermidis502000H146Q, V154L, A157R71 N128
25PresentSmallb02000H146Q, V154L, A157R71 N256
35PresentSmall02000H146Q, V154L, A157R71 N>256
4502000H146Q, V154L, A157R71 N32
623PresentLargec0000D159L128
7230000D159LK68N16
19231001000032
2023PresentLarge0000D159L128
5230000D159L8
1323PresentLarge0000D159L8
1823PresentLarge0000D159L32
2823PresentLarge0000D159L128
222310000016
1424PresentSmall04000H146Q, V154L, A157R71 N>256
15185001000A157R>256
2718604000H146Q, V154L, A157R71 N32
23186PresentSmall04000V154L, A157R71 N>256
1718604000H146Q, V154L, A157R71 N32
25186PresentSmall04000H146Q, V154L, A157R71 N>256
2618604000H146Q, V154L, A157R71 N64
21186-like04000H146Q, V154L, A157R71 N32
8S. haemolyticus10010010010064
1010010010010064
2410010010010064
1110010010010064
12100100100100128
16100100100100G139R64
910010010010064
  • a  Determined by broth microdilution.

  • b  Small (2.8- to 3.8-kb) plasmid with homology to the cfr-carrying plasmid identified in Staphylococcus cohnii (14).

  • c  Large (17-kb) plasmid with 70% homology to the cfr-carrying plasmid pSCFS1, identified in Staphylococcus sciuri (13).