TABLE 2 

Genes and promoters with SNP densities significantly higher than the chromosomal average

Locus tag(s)Gene(s)Density (SNPs/bp)P valueProductCategoryaLocalization(s)bBvgc
3783BPptxA0.011113.3E-03Pertussis toxin subunit A precursorVirE+
2416BPcysB0.010532.9E-03LysR family transcriptional regulatorRegC
BP3783PptxP0.071434.7E-18Pertussis toxin promoterVirE+
BP2936P0.036232.0E-02Putative methylase promoterExpCM+
BP1878P,
BP1879P
bvgP,
fhaBP
0.025823.4E-05Virulence factor transcription regulator promoter, filamentous hemagglutininVirC, OM+, +
BP3723P,
BP3724P
0.020471.8E-02Hypothetical protein promoterHypU, C
  • a Functional category: Vir, virulence-associated genes; Reg, regulation; Exp, exported proteins; Hyp, hypothetical proteins.

  • b Subcellular localization: E, extracellular; C, cytoplasmic; CM, cytoplasmic membrane; OM, outer membrane; U, unknown.

  • c Regulation by Bvg: +, activated; blank cells, not activated or repressed.