TABLE 1

List of amino acid substitutions between seal H3N8 and avian H3N8 virusesa

Segment (protein)nt
position
aa
position
Amino acid substitution
Seal
H3N8
(2011)
Avian
H3N8
Seal
H7N7
(1980)
Seal
H4N5
(1982)
Seal
H3N3
(1992)
Equine
H3N8
Canine
H3N8
Human
H3N2
Human
H1N1
(seasonal)
Human
H1N1
(pandemic)
1 (PB2)17860NDDDDDDDDD
441147MIIIIVVIIT
1127376RKKKKKKKKK
1144382VIIIIIIVII
2101701NDDDDNNDDD
2 (PB1)522174IMMMMMMMMM
925309GWWWWWWWWW
1075359GSSSSSSSSS
1126376VIIIIIIIII
1130377GDDDDDDDDD
1392464EDDDDDDDDD
3 (PA)25385ATTTTTTTTI
551184NSSSSSSNSS
794265LPPTPPPPPP
4 (HA)24281 (65)KTGDTTTTSN
323108 (92)SNETNSNKNS
329110 (94)SFSVFFFYED
452151 (135)EGAKGRRTVV
527176 (160)VAAAASSKLS
713238 (222)LWQWWWLRKK
778260 (244)MVTVVMMLIT
802268 (252)VIIIIVVIIV
859287 (271)NDDADDDDND
1114372KQQQQQQQQQ
1247416LSTESSSSNN
5 (NP)18763VIIIIIIIII
383128GDDDDDDDDD
886296HYYYYYYYYY
1336446GRRRRRRRKR
6 (NA)440147EVINoneIVIVVI
849283DENNoneDEEYTS
937313RGQNoneGGGSGG
958320SPLNoneHPPVFF
1186396DNNNoneNNDRII
1195399RWWNoneWWWRWW
1295432AEANoneNEEERK
8 (NS1/NS2)26388HRRRRRRRRR
  • a A total of 40 amino acid substitutions were observed in a comparison of seal H3N8 virus with avian H3N8 virus. Sequences of other seal influenza viruses, canine and equine H3N8 viruses, and selected human influenza viruses were included for comparison. Amino acid positions presented in parentheses represent corresponding H3 numbering. None, no sequence available for comparison; nt, nucleotide; aa, amino acid.