TABLE 1

Isolate description and carbapenem susceptibilitiesa

PatientIsolateSpeciesDate of
first
isolationb
Source(s)MIC (µg/ml)
determined by
Vitek 2
Imipenem
disk
diffusion
(mm)
Pulsed-
field
group
Sequence
group
PlasmidOutcome
ImipenemErtapenem
1Kox1015 Klebsiella oxytoca 8/31/2007Blood,
drain,
BAL fluid
4 ≥8 16pfg-kox1sg2pUVA02Died
Kpn1016 Klebsiella pneumoniae 8/31/2007Drain,
sputum
≥16 ≥8 16pfg-kpn1sg1pUVA01Died
2Kpn1017 Klebsiella pneumoniae 10/05/2007Blood,
sputum,
urine
8 4 17pfg-kpn1sg1pUVA01Died
3Ecl1026 Enterobacter cloacae 11/30/2007Sputum,
urine
4 ≥8 20pfg-ecl3sg1pUVA01Recovered
4Ecl1027 Enterobacter cloacae 12/09/2007Urine2 4 19pfg-ecl2sg1pUVA01Recovered
5Kox1028 Klebsiella oxytoca 1/15/2008Blood,
sputum
4 ≥8 20pfg-kox1sg2pUVA02Died
6Ecl1032 Enterobacter cloacae 1/24/2008Blood,
ascites fluid
≥16 ≥8 14pfg-ecl4sg1pUVA01Recovered
7Eco1036 Escherichia coli 2/7/2008BAL fluid≤1119n/acsg3pUVA03Recovered
8Ecl1034 Enterobacter cloacae 2/15/2008Blood,
sputum
2 ≥8 18pfg-ecl1sg1pUVA01Died
9Ecl1035 Enterobacter cloacae 2/20/2008Blood,
urine
4 ≥8 18pfg-ecl1sg1pUVA01Died
10Ecl1033 Enterobacter cloacae 2/20/2008BAL fluid,
sputum
2 ≥8 17pfg-ecl1sg1pUVA01Recovered
11Eas1043 Enterobacter asburiae 3/18/2008BAL fluid,
sputum,
wound
4 4 19n/acsg1pUVA01Died
Kpn1041 Klebsiella pneumoniae 4/8/2008Blood,
sputum
2 ≥8 21pfg-kpn2sg1pUVA01Died
12Cfr1047 Citrobacter freundii 3/21/2008Urine≤1 4 19n/acsg1pUVA01Died
13Kox1039 Klebsiella oxytoca 3/31/2008Sputum,
urine
4 ≥8 20pfg-kox1sg2pUVA02Recovered
14Kpn1042 Klebsiella pneumoniae 4/6/2008Urine≤1 ≥8 18pfg-kpn3sg1pUVA01Recovered
  • a Boldface values indicate intermediate or resistant susceptibilities by MIC testing. Patients 1 and 2 have been described previously (12).

  • b Month/day/year.

  • c n/a, not applicable.