TABLE 1 

Susceptibilities to antibiotics of P. aeruginosa wild-type and efflux-deficient strains and their hyperporinated variants

AntibioticMIC (µg/ml)a
PAO1-LACPAO1-LAC-EcPorePaΔ3-LACPaΔ3-LAC-EcPore
Bacitracin>1,02464>1,02464
Zeocin51232–64162
Rifampin160.5160.5
Vancomycin1,0241281,02464
Polymyxin B1.51.51.51.5
Nalidixic acid643282
Levofloxacin0.1250.0630.0310.004
Ciprofloxacin0.0630.0310.0160.004
Amikacin2211
Tobramycin + Mg2+210.50.5
Azithromycin128440.063
Erythromycin1282160.125
Tetracycline40.520.125
Ampicillin25616644
Carbenicillin32210.125
Cloxacillin>2,0485121288
Novobiocin51264324
Chloramphenicol8210.125
Triclosan1,0241,024328
HT (µm)>6464162
Meropenem0.50.250.1250.03
  • a Data represent results of at least three independent measurements and are expressed in micrograms per liter except as indicated.