TABLE 2 

MICs of antibiotics in B. thailandensis wild-type and efflux-deficient strains and B. cepacia and their hyperporinated variants

AntibioticsMIC (mg/liter)a
Bt-RHABt-RHA-
BtPore
BtΔ2-RHABtΔ2-RHA-
BtPore
Bc-RHABc-RHA-
BtPore
Bacitracin>1,0241,0241,0248>1,02416
Zeocin51212820.12>1,024128
Rifampin16840.0380.06
Vancomycin>1,024256–512>1,0244–8>1,0248
Polymyxin B>1,024>1,024>1,024128>1,024512
Nalidixic acid4824121.5243
Levofloxacin210.060.015620.06
Ciprofloxacin10.50.060.01610.03
Gentamicin>64>644212816
Amikacin256256421288
Kanamycin>646442644–8
Tobramycin + Mg2+64641132–644
Azithromycin1286410.032641–2
Erythromycin51225610.52568–16
Tetracycline220.1250.06>88
Doxycycline31.50.020.0163
Ampicillin2562562564>1,024512
Carbenicillin256–5122562568>1,024128
Cloxacillin256128–256320.52564
Novobiocin840.250.00880.125
Chloramphenicol8841164
Triclosan120300.120.06>12060
HT (µm)>64>6410.5>644–8
Meropenem110.250.03>40.125
  • a Data represent results of at least three independent measurements and are expressed in micrograms per liter except as indicated.