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More articles from Minireview

  • Alternative Splicing in Apicomplexan Parasites
    Minireview | Host-Microbe Biology
    Alternative Splicing in Apicomplexan Parasites

    Alternative splicing is a widespread, essential, and complex component of gene regulation. Apicomplexan parasites have long been recognized to produce alternatively spliced transcripts for some genes and can produce multiple protein products that are essential for parasite growth.

    Lee M. Yeoh, V. Vern Lee, Geoffrey I. McFadden, Stuart A. Ralph
    19 Feb 2019
  • Host-Microbe Coevolution: Applying Evidence from Model Systems to Complex Marine Invertebrate Holobionts
    Minireview | Host-Microbe Biology
    Host-Microbe Coevolution: Applying Evidence from Model Systems to Complex Marine Invertebrate Holobionts

    Marine invertebrates often host diverse microbial communities, making it difficult to identify important symbionts and to understand how these communities are structured. This complexity has also made it challenging to assign microbial functions and to unravel the myriad of interactions among the microbiota.

    Paul A. O’Brien, Nicole S. Webster, David J. Miller, David G. Bourne
    5 Feb 2019
  • Glycyl Radical Enzyme-Associated Microcompartments: Redox-Replete Bacterial Organelles
    Minireview | Molecular Biology and Physiology
    Glycyl Radical Enzyme-Associated Microcompartments: Redox-Replete Bacterial Organelles

    An increasing number of microbes are being identified that organize catabolic pathways within self-assembling proteinaceous structures known as bacterial microcompartments (BMCs). Most BMCs are characterized by their singular substrate specificity and commonly employ B12-dependent radical mechanisms.

    Bryan Ferlez, Markus Sutter, Cheryl A. Kerfeld
    8 Jan 2019
  • Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease
    Minireview | Therapeutics and Prevention
    Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease

    The concept of repurposing previously approved medications to the treatment of new indications by taking advantage of off-target effects has gained traction in recent years, particularly in areas of medicine that do not offer large profits to pharmaceutical firms. As infectious disease discovery research has declined among large pharmaceutical companies, the potential payoff of repurposing has become attractive.

    Marhiah C. Montoya, Damian J. Krysan
    18 Dec 2018
  • Evolution of the Arsenal of <span class="named-content genus-species" id="named-content-1">Legionella pneumophila</span> Effectors To Modulate Protist Hosts
    Minireview | Host-Microbe Biology
    Evolution of the Arsenal of Legionella pneumophila Effectors To Modulate Protist Hosts

    Within the human host, Legionella pneumophila replicates within alveolar macrophages, leading to pneumonia. However, L. pneumophila is an aquatic generalist pathogen that replicates within a wide variety of protist hosts, including amoebozoa, percolozoa, and ciliophora.

    Ashley Best, Yousef Abu Kwaik
    9 Oct 2018
  • Minireview | Host-Microbe Biology
    The Microbiome and Tuberculosis: Early Evidence for Cross Talk

    Tuberculosis (TB) is an ancient infectious disease of humans that has been extensively studied both clinically and experimentally. Although susceptibility to Mycobacterium tuberculosis infection is clearly influenced by factors such as nutrition, immune status, and both mycobacterial and host genetics, the variable pathogenesis of TB in infected individuals remains...

    Sivaranjani Namasivayam, Alan Sher, Michael S. Glickman, Matthew F. Wipperman
    18 Sep 2018
  • Minireview
    Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation

    The branched-chain amino acids (BCAAs [Ile, Leu, and Val]) represent important nutrients in bacterial physiology, with roles that range from supporting protein synthesis to signaling and fine-tuning the adaptation to amino acid starvation. In some pathogenic bacteria, the adaptation to amino acid starvation includes induction of virulence gene expression: thus, BCAAs support not only proliferation during infection, but also the evasion...

    Julienne C. Kaiser, David E. Heinrichs
    4 Sep 2018
  • Minireview
    Moving Forward: Recent Developments for the Ferret Biomedical Research Model

    Since the initial report in 1911, the domestic ferret has become an invaluable biomedical research model. While widely recognized for its utility in influenza virus research, ferrets are used for a variety of infectious and noninfectious disease models due to the anatomical, metabolic, and physiological features they share with humans and their susceptibility to many human pathogens.

    Randy A. Albrecht, Wen-Chun Liu, Andrea J. Sant, S. Mark Tompkins, Andrew Pekosz, Victoria Meliopoulos, Sean Cherry, Paul G. Thomas, Stacey Schultz-Cherry
    17 Jul 2018
  • Minireview
    Errors during Gene Expression: Single-Cell Heterogeneity, Stress Resistance, and Microbe-Host Interactions
    Christopher R. Evans, Yongqiang Fan, Kalyn Weiss, Jiqiang Ling
    3 Jul 2018
  • Minireview
    Bacterial Quorum Sensing and Microbial Community Interactions
    Rhea G. Abisado, Saida Benomar, Jennifer R. Klaus, Ajai A. Dandekar, Josephine R. Chandler
    22 May 2018

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