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Commentary | Host-Microbe Biology

In Fungal Intracellular Pathogenesis, Form Determines Fate

Robin C. May, Arturo Casadevall
Robin C. May
aInstitute of Microbiology & Infection, University of Birmingham, Birmingham, United Kingdom
bSchool of Biosciences, University of Birmingham, Birmingham, United Kingdom
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Arturo Casadevall
cDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA
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DOI: 10.1128/mBio.02092-18
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ABSTRACT

For pathogenic microbes to survive ingestion by macrophages, they must subvert powerful microbicidal mechanisms within the phagolysosome. After ingestion, Candida albicans undergoes a morphological transition producing hyphae, while the surrounding phagosome exhibits a loss of phagosomal acidity. However, how these two events are related has remained enigmatic. Now Westman et al. (mBio 9:e01226-18, 2018, https://doi.org/10.1128/mBio.01226-18) report that phagosomal neutralization results from disruption of phagosomal membrane integrity by the enlarging hyphae, directly implicating the morphological transition in physical damage that promotes intracellular survival. The C. albicans intracellular strategy shows parallels with another fungal pathogen, Cryptococcus neoformans, where a morphological changed involving capsular enlargement intracellularly is associated with loss of membrane integrity and death of the host cell. These similarities among distantly related pathogenic fungi suggest that morphological transitions that are common in fungi directly affect the outcome of the fungal cell-macrophage interaction. For this class of organisms, form determines fate in the intracellular environment.

The views expressed in this Commentary do not necessarily reflect the views of this journal or of ASM.

FOOTNOTES

    • Published 23 October 2018
  • For the article discussed, see https://doi.org/10.1128/mBio.01226-18.

  • Copyright © 2018 May and Casadevall.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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In Fungal Intracellular Pathogenesis, Form Determines Fate
Robin C. May, Arturo Casadevall
mBio Oct 2018, 9 (5) e02092-18; DOI: 10.1128/mBio.02092-18

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In Fungal Intracellular Pathogenesis, Form Determines Fate
Robin C. May, Arturo Casadevall
mBio Oct 2018, 9 (5) e02092-18; DOI: 10.1128/mBio.02092-18
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KEYWORDS

Candida
Cryptococcus
fungus
macrophage
phagosome

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