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Research Article

Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus

Alexander Kühnl, Agnes Musiol, Nicole Heitzig, Danielle E. Johnson, Christina Ehrhardt, Thomas Grewal, Volker Gerke, Stephan Ludwig, Ursula Rescher
Jean Gruenberg, Invited Editor, Scott D. Emr, Editor
Alexander Kühnl
aInstitute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Muenster, Muenster, Germany
cInterdisciplinary Centre for Clinical Research, University of Muenster, Muenster, Germany
dCluster of Excellence “Cells in Motion,” University of Muenster, Muenster, Germany
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Agnes Musiol
aInstitute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Muenster, Muenster, Germany
cInterdisciplinary Centre for Clinical Research, University of Muenster, Muenster, Germany
dCluster of Excellence “Cells in Motion,” University of Muenster, Muenster, Germany
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Nicole Heitzig
aInstitute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Muenster, Muenster, Germany
cInterdisciplinary Centre for Clinical Research, University of Muenster, Muenster, Germany
dCluster of Excellence “Cells in Motion,” University of Muenster, Muenster, Germany
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Danielle E. Johnson
eProgram in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
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Christina Ehrhardt
bInstitute of Virology, Center for Molecular Biology of Inflammation, University of Muenster, Muenster, Germany
cInterdisciplinary Centre for Clinical Research, University of Muenster, Muenster, Germany
dCluster of Excellence “Cells in Motion,” University of Muenster, Muenster, Germany
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Thomas Grewal
fFaculty of Pharmacy A15, University of Sydney, Sydney, NSW, Australia
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Volker Gerke
aInstitute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Muenster, Muenster, Germany
cInterdisciplinary Centre for Clinical Research, University of Muenster, Muenster, Germany
dCluster of Excellence “Cells in Motion,” University of Muenster, Muenster, Germany
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Stephan Ludwig
bInstitute of Virology, Center for Molecular Biology of Inflammation, University of Muenster, Muenster, Germany
cInterdisciplinary Centre for Clinical Research, University of Muenster, Muenster, Germany
dCluster of Excellence “Cells in Motion,” University of Muenster, Muenster, Germany
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Ursula Rescher
aInstitute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Muenster, Muenster, Germany
cInterdisciplinary Centre for Clinical Research, University of Muenster, Muenster, Germany
dCluster of Excellence “Cells in Motion,” University of Muenster, Muenster, Germany
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Jean Gruenberg
University of Geneva
Roles: Invited Editor
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Scott D. Emr
Cornell University
Roles: Editor
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DOI: 10.1128/mBio.01345-18
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Article Information

DOI 
https://doi.org/10.1128/mBio.01345-18
PubMed 
30042202

Published By 
American Society for Microbiology
History 
  • Received June 19, 2018
  • Accepted June 27, 2018
  • Published online July 24, 2018.

Copyright & Usage 
Copyright © 2018 Kühnl et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Jean Gruenberg, Invited Editor, University of Geneva
  • Scott D. Emr, Editor, Cornell University

Author Information

  1. Alexander Kühnla,c,d,
  2. Agnes Musiola,c,d,
  3. Nicole Heitziga,c,d,
  4. Danielle E. Johnsone,
  5. Christina Ehrhardtb,c,d,
  6. Thomas Grewalf,
  7. Volker Gerkea,c,d,
  8. Stephan Ludwigb,c,d,
  9. Ursula Reschera,c,d
  1. aInstitute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Muenster, Muenster, Germany
  2. bInstitute of Virology, Center for Molecular Biology of Inflammation, University of Muenster, Muenster, Germany
  3. cInterdisciplinary Centre for Clinical Research, University of Muenster, Muenster, Germany
  4. dCluster of Excellence “Cells in Motion,” University of Muenster, Muenster, Germany
  5. eProgram in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
  6. fFaculty of Pharmacy A15, University of Sydney, Sydney, NSW, Australia
  • Address correspondence to Ursula Rescher, rescher{at}uni-muenster.de.
  • Citation Kühnl A, Musiol A, Heitzig N, Johnson DE, Ehrhardt C, Grewal T, Gerke V, Ludwig S, Rescher U. 2018. Late endosomal/lysosomal cholesterol accumulation is a host cell-protective mechanism inhibiting endosomal escape of influenza A virus. mBio 9:e01345-18. https://doi.org/10.1128/mBio.01345-18.

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Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus
Alexander Kühnl, Agnes Musiol, Nicole Heitzig, Danielle E. Johnson, Christina Ehrhardt, Thomas Grewal, Volker Gerke, Stephan Ludwig, Ursula Rescher
mBio Jul 2018, 9 (4) e01345-18; DOI: 10.1128/mBio.01345-18

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Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus
Alexander Kühnl, Agnes Musiol, Nicole Heitzig, Danielle E. Johnson, Christina Ehrhardt, Thomas Grewal, Volker Gerke, Stephan Ludwig, Ursula Rescher
mBio Jul 2018, 9 (4) e01345-18; DOI: 10.1128/mBio.01345-18
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KEYWORDS

IFITM3
influenza A virus
annexin A6
interferon
late endosomal cholesterol content

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