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Research Article

An Evolutionarily Conserved Mechanism for Intrinsic and Transferable Polymyxin Resistance

Yongchang Xu, Wenhui Wei, Sheng Lei, Jingxia Lin, Swaminath Srinivas, Youjun Feng
Gian Maria Rossolini, Invited Editor, Karen Bush, Editor
Yongchang Xu
aDepartment of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
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Wenhui Wei
aDepartment of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
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Sheng Lei
aDepartment of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
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Jingxia Lin
aDepartment of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
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Swaminath Srinivas
cDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
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Youjun Feng
aDepartment of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
bCollege of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Gian Maria Rossolini
University of Siena
Roles: Invited Editor
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Karen Bush
Indiana University Bloomington
Roles: Editor
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DOI: 10.1128/mBio.02317-17
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Article Information

DOI 
https://doi.org/10.1128/mBio.02317-17
PubMed 
29636432

Published By 
American Society for Microbiology
History 
  • Received December 12, 2017
  • Accepted March 8, 2018
  • Published online April 10, 2018.

Copyright & Usage 
Copyright © 2018 Xu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Gian Maria Rossolini, Invited Editor, University of Siena
  • Karen Bush, Editor, Indiana University Bloomington

Author Information

  1. Yongchang Xua,
  2. Wenhui Weia,
  3. Sheng Leia,
  4. Jingxia Lina,
  5. Swaminath Srinivasc,
  6. Youjun Fenga,b
  1. aDepartment of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
  2. bCollege of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China
  3. cDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
  • Address correspondence to Youjun Feng, fengyj{at}zju.edu.cn.
  • Y.X., W.W., and S.L. contributed equally to this work.

  • Citation Xu Y, Wei W, Lei S, Lin J, Srinivas S, Feng Y. 2018. An evolutionarily conserved mechanism for intrinsic and transferable polymyxin resistance. mBio 9:e02317-17. https://doi.org/10.1128/mBio.02317-17.

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An Evolutionarily Conserved Mechanism for Intrinsic and Transferable Polymyxin Resistance
Yongchang Xu, Wenhui Wei, Sheng Lei, Jingxia Lin, Swaminath Srinivas, Youjun Feng
mBio Apr 2018, 9 (2) e02317-17; DOI: 10.1128/mBio.02317-17

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An Evolutionarily Conserved Mechanism for Intrinsic and Transferable Polymyxin Resistance
Yongchang Xu, Wenhui Wei, Sheng Lei, Jingxia Lin, Swaminath Srinivas, Youjun Feng
mBio Apr 2018, 9 (2) e02317-17; DOI: 10.1128/mBio.02317-17
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KEYWORDS

enteric bacteria
EptA
lipid A
MCR-1
MCR-2
polymyxin resistance
substrate cavity

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