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Research Article

Listeria monocytogenes Source Distribution Analysis Indicates Regional Heterogeneity and Ecological Niche Preference among Serotype 4b Clones

Sangmi Lee, Yi Chen, Lisa Gorski, Todd J. Ward, Jason Osborne, Sophia Kathariou
Nancy E. Freitag, Editor
Sangmi Lee
aDepartment of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, North Carolina, USA
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Yi Chen
cDivision of Microbiology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA
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Lisa Gorski
dProduce Safety and Microbiology Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Albany, California, USA
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Todd J. Ward
eAgricultural Research Service, U.S. Department of Agriculture, Peoria, Illinois, USA
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Jason Osborne
bDepartment of Statistics, North Carolina State University, Raleigh, North Carolina, USA
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Sophia Kathariou
aDepartment of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, North Carolina, USA
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Nancy E. Freitag
University of Illinois at Chicago
Roles: Editor
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James Lindsay
USDA-ARS
Roles: Solicited external reviewer
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Wei Zhang
Illinois Institute of Technology
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Jose Vazquez-Boland
University of Edinburgh
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DOI: 10.1128/mBio.00396-18
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  • FIG 1 
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    FIG 1 

    L. monocytogenes clones in the serotype 4b strain panel. Relative abundance of each clone in the panel is shown in decreasing order. CC indicates clonal complex, and singletons are indicated with the corresponding sequence type (ST). “Unique” is a group that consists of four lineage I clones (CC218, ST688, ST1061, and ST1256) encountered only once in the panel and the lineage IV clone ST563 (Table S2). “LIII” consists of the 17 lineage III isolates (Tables S1 and S2). Color codes for each source are shown at right (red, human; blue, food; green, environment; purple, animal). Source designations are as described in Materials and Methods and in Tables S1 and S2. Significantly different distributions of specific clones across all sources are indicated with **** (P < 0.0001).

  • FIG 2 
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    FIG 2 

    MST of the lineage I serotype 4b isolates. An MST was constructed for the 16 lineage I clones that were encountered among ≥2 isolates. A commonly encountered ST of each CC was arbitrarily chosen to construct the MST. Lineage III clones are included at the bottom of the figure (“LIII”) but are not part of the MST. Unique lineage I clones (encountered only once) and the sole lineage IV clone are also included (“Unique”) at the bottom of the figure but are not part of the MST. Each clonal group is illustrated as a pie chart, with different colors representing different sources (red, human; blue, food; green, environment; purple, animal). The CC and ST designations are included near each pie chart. The size of each circle is proportional to the log value of the number of strains in each clone. Numbers on the connecting lines represent the number of allelic differences between clones.

  • FIG 3 
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    FIG 3 

    Numerical representation of clones from each source. Sources are human (A), food (B), environment (C), and animals (D). Source designations, CC and ST designations, and the group designations “Unique” and “LIII” are as in Fig. 1.

  • FIG 4 
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    FIG 4 

    Numerical representation of each clone in pairwise comparisons between sources. Source comparisons are food versus human (A), environment versus human (B), environment versus food (C), animal versus human (D), animal versus food (E), and animal versus environment (F). Source designations, CC and ST designations, and the group designations “Unique” and “LIII” are as in Fig. 1. Significantly different distributions between sources are indicated with *, **, ***, and **** (P < 0.05, 0.01, 0.001, and 0.0001, respectively).

Supplemental Material

  • Figures
  • TABLE S1 

    List of serotype 4b Listeria monocytogenes isolates investigated in this study. Download TABLE S1, DOCX file, 0.04 MB.

    Copyright © 2018 Lee et al.

    This content is distributed under the terms of the Creative Commons Attribution 4.0 International license.

  • TABLE S2 

    Statistical analysis of the source distribution of serotype 4b Listeria monocytogenes clones. Download TABLE S2, DOCX file, 0.02 MB.

    Copyright © 2018 Lee et al.

    This content is distributed under the terms of the Creative Commons Attribution 4.0 International license.

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Listeria monocytogenes Source Distribution Analysis Indicates Regional Heterogeneity and Ecological Niche Preference among Serotype 4b Clones
Sangmi Lee, Yi Chen, Lisa Gorski, Todd J. Ward, Jason Osborne, Sophia Kathariou
mBio Apr 2018, 9 (2) e00396-18; DOI: 10.1128/mBio.00396-18

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Listeria monocytogenes Source Distribution Analysis Indicates Regional Heterogeneity and Ecological Niche Preference among Serotype 4b Clones
Sangmi Lee, Yi Chen, Lisa Gorski, Todd J. Ward, Jason Osborne, Sophia Kathariou
mBio Apr 2018, 9 (2) e00396-18; DOI: 10.1128/mBio.00396-18
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KEYWORDS

Listeria monocytogenes
source distribution
emerging clones
serotype 4b

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