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Editor's Pick Research Article

Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model

Henning Jacobsen, Madhusudan Rajendran, Angela Choi, Haakon Sjursen, Karl A. Brokstad, Rebecca J. Cox, Peter Palese, Florian Krammer, Raffael Nachbagauer
Rino Rappuoli, Editor
Henning Jacobsen
a Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Madhusudan Rajendran
a Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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  • ORCID record for Madhusudan Rajendran
Angela Choi
a Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
b Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Haakon Sjursen
c Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway
d Section for Infectious Diseases, Medical Department, Haukeland University Hospital, Bergen, Norway
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Karl A. Brokstad
e Department of Clinical Science, Broeglemann Research Laboratory, University of Bergen, Bergen, Norway
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Rebecca J. Cox
d Section for Infectious Diseases, Medical Department, Haukeland University Hospital, Bergen, Norway
f KG Jebsen Centre for Influenza Vaccine Research, Department of Clinical Science, University of Bergen, Bergen, Norway
g Department of Research and Development, Haukeland University Hospital, Bergen, Norway
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Peter Palese
a Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Florian Krammer
a Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Raffael Nachbagauer
a Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Rino Rappuoli
GSK Vaccines
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Mark Mulligan
Emory University
Roles: Solicited external reviewer
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Daniel Perez
University of Georgia
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DOI: 10.1128/mBio.01463-17
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Article Information

DOI 
https://doi.org/10.1128/mBio.01463-17
PubMed 
28928215

Published By 
American Society for Microbiology
History 
  • Received August 15, 2017
  • Accepted August 21, 2017
  • Published online September 19, 2017.

Copyright & Usage 
Copyright © 2017 Jacobsen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license .
Editors and / or Reviewers 
  • Rino Rappuoli, Editor, GSK Vaccines
  • Mark Mulligan, Solicited external reviewer, Emory University
  • Daniel Perez, Solicited external reviewer, University of Georgia

Author Information

  1. Henning Jacobsena*,
  2. Madhusudan Rajendrana,
  3. Angela Choia,b,
  4. Haakon Sjursenc,d,
  5. Karl A. Brokstade,
  6. Rebecca J. Coxd,f,g,
  7. Peter Palesea,
  8. Florian Krammera,
  9. Raffael Nachbagauera
  1. a Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  2. b Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  3. c Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway
  4. d Section for Infectious Diseases, Medical Department, Haukeland University Hospital, Bergen, Norway
  5. e Department of Clinical Science, Broeglemann Research Laboratory, University of Bergen, Bergen, Norway
  6. f KG Jebsen Centre for Influenza Vaccine Research, Department of Clinical Science, University of Bergen, Bergen, Norway
  7. g Department of Research and Development, Haukeland University Hospital, Bergen, Norway
  • Address correspondence to Raffael Nachbagauer, raffael.nachbagauer{at}mssm.edu.
  • Citation Jacobsen H, Rajendran M, Choi A, Sjursen H, Brokstad KA, Cox RJ, Palese P, Krammer F, Nachbagauer R. 2017. Influenza virus hemagglutinin stalk-specific antibodies in human serum are a surrogate marker for in vivo protection in a serum transfer mouse challenge model. mBio 8:e01463-17. https://doi.org/10.1128/mBio.01463-17 .

  • ↵* Present address: Henning Jacobsen, Heinrich Pette Institute, Leibniz Institute of Experimental Virology, Hamburg, Germany.

  1. This article is a direct contribution from a Fellow of the American Academy of Microbiology.

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Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model
Henning Jacobsen, Madhusudan Rajendran, Angela Choi, Haakon Sjursen, Karl A. Brokstad, Rebecca J. Cox, Peter Palese, Florian Krammer, Raffael Nachbagauer
mBio Sep 2017, 8 (5) e01463-17; DOI: 10.1128/mBio.01463-17

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Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model
Henning Jacobsen, Madhusudan Rajendran, Angela Choi, Haakon Sjursen, Karl A. Brokstad, Rebecca J. Cox, Peter Palese, Florian Krammer, Raffael Nachbagauer
mBio Sep 2017, 8 (5) e01463-17; DOI: 10.1128/mBio.01463-17
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KEYWORDS

Antibodies, Viral
Hemagglutinin Glycoproteins, Influenza Virus
Immunization, Passive
Immunogenicity, Vaccine
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H5N1 Subtype
Orthomyxoviridae Infections
ADCC
ELISA
correlate of protection
hemagglutinin
hemagglutinin stalk
influenza
influenza vaccines
surrogate marker
universal influenza virus vaccine

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