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Research Article

Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate

Erin E. H. Tran, Kira A. Podolsky, Alberto Bartesaghi, Oleg Kuybeda, Giovanna Grandinetti, Teddy John Wohlbold, Gene S. Tan, Raffael Nachbagauer, Peter Palese, Florian Krammer, Sriram Subramaniam
Yasuko Rikihisa, Editor
Erin E. H. Tran
aCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Kira A. Podolsky
aCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Alberto Bartesaghi
aCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Oleg Kuybeda
aCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Giovanna Grandinetti
aCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Teddy John Wohlbold
bDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
cGraduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Gene S. Tan
bDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Raffael Nachbagauer
bDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
dFaculty of Life Sciences, University of Vienna, Vienna, Austria
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Peter Palese
bDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
eDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Florian Krammer
bDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Sriram Subramaniam
aCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Yasuko Rikihisa
Ohio State University
Roles: Editor
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Michael Farzan
The Scripps Research Institute
Roles: Solicited external reviewer
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Richard J. Kuhn
Purdue University
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DOI: 10.1128/mBio.00257-16
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Article Information

DOI 
https://doi.org/10.1128/mBio.00257-16
PubMed 
27006464

Published By 
American Society for Microbiology
History 
  • Received February 16, 2016
  • Accepted February 17, 2016
  • Published online March 22, 2016.

Copyright & Usage 
Copyright © 2016 Tran et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Yasuko Rikihisa, Editor, Ohio State University
  • Michael Farzan, Solicited external reviewer, The Scripps Research Institute
  • Richard J. Kuhn, Solicited external reviewer, Purdue University

Author Information

  1. Erin E. H. Trana,
  2. Kira A. Podolskya,
  3. Alberto Bartesaghia,
  4. Oleg Kuybedaa,
  5. Giovanna Grandinettia,
  6. Teddy John Wohlboldb,c,
  7. Gene S. Tanb,
  8. Raffael Nachbagauerb,d,
  9. Peter Paleseb,e,
  10. Florian Krammerb,
  11. Sriram Subramaniama
  1. aCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
  2. bDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  3. cGraduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  4. dFaculty of Life Sciences, University of Vienna, Vienna, Austria
  5. eDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  • Address correspondence to Sriram Subramaniam, ss1{at}nih.gov.
  • E.E.H.T. and K.A.P. contributed equally to this work.

  • Citation Tran EEH, Podolsky KA, Bartesaghi A, Kuybeda O, Grandinetti G, Wohlbold TJ, Tan GS, Nachbagauer R, Palese P, Krammer F, Subramaniam S. 2016. Cryo-electron microscopy structures of chimeric hemagglutinin displayed on a universal influenza vaccine candidate. mBio 7(2):e00257-16. doi:10.1128/mBio.00257-16.

  1. This article is a direct contribution from a Fellow of the American Academy of Microbiology.

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Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate
Erin E. H. Tran, Kira A. Podolsky, Alberto Bartesaghi, Oleg Kuybeda, Giovanna Grandinetti, Teddy John Wohlbold, Gene S. Tan, Raffael Nachbagauer, Peter Palese, Florian Krammer, Sriram Subramaniam
mBio Mar 2016, 7 (2) e00257-16; DOI: 10.1128/mBio.00257-16

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Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate
Erin E. H. Tran, Kira A. Podolsky, Alberto Bartesaghi, Oleg Kuybeda, Giovanna Grandinetti, Teddy John Wohlbold, Gene S. Tan, Raffael Nachbagauer, Peter Palese, Florian Krammer, Sriram Subramaniam
mBio Mar 2016, 7 (2) e00257-16; DOI: 10.1128/mBio.00257-16
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