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Research Article

Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I

Jie Xu, Xiomara Mercado-López, Jennifer T. Grier, Won-keun Kim, Lauren F. Chun, Edward B. Irvine, Yoandris Del Toro Duany, Alison Kell, Sun Hur, Michael Gale Jr., Arjun Raj, Carolina B. López
Michael J. Buchmeier, Editor
Jie Xu
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Xiomara Mercado-López
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Jennifer T. Grier
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Won-keun Kim
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Lauren F. Chun
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Edward B. Irvine
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Yoandris Del Toro Duany
bDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
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Alison Kell
cDepartment of Immunology, University of Washington School of Medicine, Seattle, Washington, USA
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Sun Hur
bDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
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Michael Gale Jr.
cDepartment of Immunology, University of Washington School of Medicine, Seattle, Washington, USA
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Arjun Raj
dDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Carolina B. López
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Michael J. Buchmeier
University of California, Irvine
Roles: Editor
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DOI: 10.1128/mBio.01265-15
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Article Information

DOI 
https://doi.org/10.1128/mBio.01265-15
PubMed 
26443454

Published By 
American Society for Microbiology
History 
  • Received July 28, 2015
  • Accepted September 11, 2015
  • Published online October 6, 2015.

Copyright & Usage 
Copyright © 2015 Xu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
Editors and / or Reviewers 
  • Michael J. Buchmeier, Editor, University of California, Irvine

Author Information

  1. Jie Xua,
  2. Xiomara Mercado-Lópeza,
  3. Jennifer T. Griera,
  4. Won-keun Kima,
  5. Lauren F. Chuna,
  6. Edward B. Irvinea,
  7. Yoandris Del Toro Duanyb,
  8. Alison Kellc,
  9. Sun Hurb,
  10. Michael Gale, Jr.c,
  11. Arjun Rajd,
  12. Carolina B. Lópeza
  1. aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
  2. bDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
  3. cDepartment of Immunology, University of Washington School of Medicine, Seattle, Washington, USA
  4. dDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
  • Address correspondence to Carolina B. López, lopezca{at}vet.upenn.edu.
  • Citation Xu J, Mercado-López X, Grier JT, Kim W, Chun LF, Irvine EB, Del Toro Duany Y, Kell A, Hur S, Gale M, Jr., Raj A, López CB. 2015. Identification of a natural viral RNA motif that optimizes sensing of viral RNA by RIG-I. mBio 6(5):e01265-15. doi:10.1128/mBio.01265-15.

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Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I
Jie Xu, Xiomara Mercado-López, Jennifer T. Grier, Won-keun Kim, Lauren F. Chun, Edward B. Irvine, Yoandris Del Toro Duany, Alison Kell, Sun Hur, Michael Gale Jr., Arjun Raj, Carolina B. López
mBio Oct 2015, 6 (5) e01265-15; DOI: 10.1128/mBio.01265-15

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Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I
Jie Xu, Xiomara Mercado-López, Jennifer T. Grier, Won-keun Kim, Lauren F. Chun, Edward B. Irvine, Yoandris Del Toro Duany, Alison Kell, Sun Hur, Michael Gale Jr., Arjun Raj, Carolina B. López
mBio Oct 2015, 6 (5) e01265-15; DOI: 10.1128/mBio.01265-15
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