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Research Article

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

Visesato Mor, Antonella Rella, Amir M. Farnoud, Ashutosh Singh, Mansa Munshi, Arielle Bryan, Shamoon Naseem, James B. Konopka, Iwao Ojima, Erika Bullesbach, Alan Ashbaugh, Michael J. Linke, Melanie Cushion, Margaret Collins, Hari Krishna Ananthula, Larry Sallans, Pankaj B. Desai, Nathan P. Wiederhold, Annette W. Fothergill, William R. Kirkpatrick, Thomas Patterson, Lai Hong Wong, Sunita Sinha, Guri Giaever, Corey Nislow, Patrick Flaherty, Xuewen Pan, Gabriele Vargas Cesar, Patricia de Melo Tavares, Susana Frases, Kildare Miranda, Marcio L. Rodrigues, Chiara Luberto, Leonardo Nimrichter, Maurizio Del Poeta
Julian E. Davies, Editor
Visesato Mor
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
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Antonella Rella
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
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Amir M. Farnoud
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
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Ashutosh Singh
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
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Mansa Munshi
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
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Arielle Bryan
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
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Shamoon Naseem
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
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James B. Konopka
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
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Iwao Ojima
Department of Chemistry and Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York, USA
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Erika Bullesbach
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA
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Alan Ashbaugh
Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA
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Michael J. Linke
Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USAUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA
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Melanie Cushion
Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USAUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA
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Margaret Collins
University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
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Hari Krishna Ananthula
Department of Pharmaceutical Sciences, University of Cincinnati, Cincinnati, Ohio, USA
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Larry Sallans
Department of Chemistry, University of Cincinnati, Cincinnati, Ohio, USA
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Pankaj B. Desai
Department of Pharmaceutical Sciences, University of Cincinnati, Cincinnati, Ohio, USA
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Nathan P. Wiederhold
Department of Pathology, Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
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Annette W. Fothergill
Department of Pathology, Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
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William R. Kirkpatrick
Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
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Thomas Patterson
Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
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Lai Hong Wong
Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Colombia, Canada
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Sunita Sinha
Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Colombia, Canada
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Guri Giaever
Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Colombia, Canada
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Corey Nislow
Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Colombia, Canada
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Patrick Flaherty
Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, USA
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Xuewen Pan
Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA
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Gabriele Vargas Cesar
Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Patricia de Melo Tavares
Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Susana Frases
Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Kildare Miranda
Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilDiretoria de Metrologia Aplicada a Ciências da Vida, Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO), Xerém, Rio de Janeiro, Brazil
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Marcio L. Rodrigues
Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilFundação Oswaldo Cruz (Fiocruz), Centro de Desenvolvimento Tecnológico em Saúde (CDTS), Rio de Janeiro, Brazil
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Chiara Luberto
Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York, USA
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Leonardo Nimrichter
Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Maurizio Del Poeta
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
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Julian E. Davies
University of British Columbia
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DOI: 10.1128/mBio.00647-15
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Article Information

DOI 
https://doi.org/10.1128/mBio.00647-15
PubMed 
26106079

Published By 
American Society for Microbiology
History 
  • Received April 20, 2015
  • Accepted May 19, 2015
  • Published online June 23, 2015.

Copyright & Usage 
Copyright © 2015 Mor et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
Editors and / or Reviewers 
  • Julian E. Davies, Editor, University of British Columbia

Author Information

  1. Visesato Mora,
  2. Antonella Rellaa,
  3. Amir M. Farnouda,
  4. Ashutosh Singha,
  5. Mansa Munshia,
  6. Arielle Bryana,
  7. Shamoon Naseema,
  8. James B. Konopkaa,
  9. Iwao Ojimab,
  10. Erika Bullesbachc,
  11. Alan Ashbaughd,
  12. Michael J. Linked,e,
  13. Melanie Cushiond,e,
  14. Margaret Collinse,
  15. Hari Krishna Ananthulaf,
  16. Larry Sallansq,
  17. Pankaj B. Desaif,
  18. Nathan P. Wiederholdg,
  19. Annette W. Fothergillg,
  20. William R. Kirkpatrickh,
  21. Thomas Pattersonh,
  22. Lai Hong Wongi,
  23. Sunita Sinhai,
  24. Guri Giaeveri,
  25. Corey Nislowi,
  26. Patrick Flahertyj,
  27. Xuewen Pank,
  28. Gabriele Vargas Cesarl,
  29. Patricia de Melo Tavaresl,
  30. Susana Frasesm,
  31. Kildare Mirandal,n,
  32. Marcio L. Rodriguesl,o,
  33. Chiara Lubertop,
  34. Leonardo Nimrichterl,
  35. Maurizio Del Poetaa
  1. aDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
  2. bDepartment of Chemistry and Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York, USA
  3. cDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA
  4. dDepartment of Veterans Affairs Medical Center, Cincinnati, Ohio, USA
  5. eUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA
  6. fDepartment of Pharmaceutical Sciences, University of Cincinnati, Cincinnati, Ohio, USA
  7. gDepartment of Pathology, Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
  8. hDivision of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
  9. iDepartment of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Colombia, Canada
  10. jDepartment of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, USA
  11. kDepartment of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA
  12. lInstituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  13. mLaboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  14. nDiretoria de Metrologia Aplicada a Ciências da Vida, Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO), Xerém, Rio de Janeiro, Brazil
  15. oFundação Oswaldo Cruz (Fiocruz), Centro de Desenvolvimento Tecnológico em Saúde (CDTS), Rio de Janeiro, Brazil
  16. pDepartment of Physiology and Biophysics, Stony Brook University, Stony Brook, New York, USA
  17. qDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio, USA
  • Address correspondence to Maurizio Del Poeta, maurizio.delpoeta{at}stonybrook.edu.
  • Citation Mor V, Rella A, Farnoud AM, Singh A, Munshi M, Bryan A, Naseem S, Konopka JB, Ojima I, Bullesbach E, Ashbaugh A, Linke MJ, Cushion M, Collins M, Ananthula HK, Sallans L, Desai PB, Wiederhold NP, Fothergill AW, Kirkpatrick WR, Patterson T, Wong LH, Sinha S, Giaever G, Nislow C, Flaherty P, Pan X, Cesar GV, de Melo Tavares P, Frases S, Miranda K, Rodrigues ML, Luberto C, Nimrichter L, Del Poeta M. 2015. Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids. mBio 6(3):e00647-15. doi:10.1128/mBio.00647-15.

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Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids
Visesato Mor, Antonella Rella, Amir M. Farnoud, Ashutosh Singh, Mansa Munshi, Arielle Bryan, Shamoon Naseem, James B. Konopka, Iwao Ojima, Erika Bullesbach, Alan Ashbaugh, Michael J. Linke, Melanie Cushion, Margaret Collins, Hari Krishna Ananthula, Larry Sallans, Pankaj B. Desai, Nathan P. Wiederhold, Annette W. Fothergill, William R. Kirkpatrick, Thomas Patterson, Lai Hong Wong, Sunita Sinha, Guri Giaever, Corey Nislow, Patrick Flaherty, Xuewen Pan, Gabriele Vargas Cesar, Patricia de Melo Tavares, Susana Frases, Kildare Miranda, Marcio L. Rodrigues, Chiara Luberto, Leonardo Nimrichter, Maurizio Del Poeta
mBio Jun 2015, 6 (3) e00647-15; DOI: 10.1128/mBio.00647-15

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Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids
Visesato Mor, Antonella Rella, Amir M. Farnoud, Ashutosh Singh, Mansa Munshi, Arielle Bryan, Shamoon Naseem, James B. Konopka, Iwao Ojima, Erika Bullesbach, Alan Ashbaugh, Michael J. Linke, Melanie Cushion, Margaret Collins, Hari Krishna Ananthula, Larry Sallans, Pankaj B. Desai, Nathan P. Wiederhold, Annette W. Fothergill, William R. Kirkpatrick, Thomas Patterson, Lai Hong Wong, Sunita Sinha, Guri Giaever, Corey Nislow, Patrick Flaherty, Xuewen Pan, Gabriele Vargas Cesar, Patricia de Melo Tavares, Susana Frases, Kildare Miranda, Marcio L. Rodrigues, Chiara Luberto, Leonardo Nimrichter, Maurizio Del Poeta
mBio Jun 2015, 6 (3) e00647-15; DOI: 10.1128/mBio.00647-15
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