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Research Article

A Modified R-Type Bacteriocin Specifically Targeting Clostridium difficile Prevents Colonization of Mice without Affecting Gut Microbiota Diversity

Dana Gebhart, Stephen Lok, Simon Clare, Myreen Tomas, Mark Stares, Dean Scholl, Curtis J. Donskey, Trevor D. Lawley, Gregory R. Govoni
Anne K. Vidaver, Editor
Dana Gebhart
aAvidBiotics Corp., South San Francisco, California, USA
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Stephen Lok
aAvidBiotics Corp., South San Francisco, California, USA
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Simon Clare
bMicrobial Pathogenesis Laboratory, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Myreen Tomas
cGeriatric Research Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
dDivision of Infectious Diseases & HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
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Mark Stares
eHost Microbiota Interactions Laboratory, Wellcome Trust Sanger Institute, Hinxton, United Kingdome
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Dean Scholl
aAvidBiotics Corp., South San Francisco, California, USA
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Curtis J. Donskey
cGeriatric Research Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
dDivision of Infectious Diseases & HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
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Trevor D. Lawley
eHost Microbiota Interactions Laboratory, Wellcome Trust Sanger Institute, Hinxton, United Kingdome
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Gregory R. Govoni
aAvidBiotics Corp., South San Francisco, California, USA
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Anne K. Vidaver
University of Nebraska
Roles: Editor
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DOI: 10.1128/mBio.02368-14
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Article Information

DOI 
https://doi.org/10.1128/mBio.02368-14
PubMed 
25805733

Published By 
American Society for Microbiology
History 
  • Received November 21, 2014
  • Accepted February 16, 2015
  • Published online March 24, 2015.

Copyright & Usage 
Copyright © 2015 Gebhart et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.
Editors and / or Reviewers 
  • Anne K. Vidaver, Editor, University of Nebraska

Author Information

  1. Dana Gebharta,
  2. Stephen Loka,
  3. Simon Clareb,
  4. Myreen Tomasc,d,
  5. Mark Starese,
  6. Dean Scholla,
  7. Curtis J. Donskeyc,d,
  8. Trevor D. Lawleye,
  9. Gregory R. Govonia
  1. aAvidBiotics Corp., South San Francisco, California, USA
  2. bMicrobial Pathogenesis Laboratory, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
  3. cGeriatric Research Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
  4. dDivision of Infectious Diseases & HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
  5. eHost Microbiota Interactions Laboratory, Wellcome Trust Sanger Institute, Hinxton, United Kingdome
  • Address correspondence to Gregory R. Govoni, greg{at}avidbiotics.com.
  • Citation Gebhart D, Lok S, Clare S, Tomas M, Stares M, Scholl D, Donskey CJ, Lawley TD, Govoni GR. 2015. A modified R-type bacteriocin specifically targeting Clostridium difficile prevents colonization of mice without affecting gut microbiota diversity. mBio 6(2):e02368-14. doi:10.1128/mBio.02368-14.

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A Modified R-Type Bacteriocin Specifically Targeting Clostridium difficile Prevents Colonization of Mice without Affecting Gut Microbiota Diversity
Dana Gebhart, Stephen Lok, Simon Clare, Myreen Tomas, Mark Stares, Dean Scholl, Curtis J. Donskey, Trevor D. Lawley, Gregory R. Govoni
mBio Mar 2015, 6 (2) e02368-14; DOI: 10.1128/mBio.02368-14

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A Modified R-Type Bacteriocin Specifically Targeting Clostridium difficile Prevents Colonization of Mice without Affecting Gut Microbiota Diversity
Dana Gebhart, Stephen Lok, Simon Clare, Myreen Tomas, Mark Stares, Dean Scholl, Curtis J. Donskey, Trevor D. Lawley, Gregory R. Govoni
mBio Mar 2015, 6 (2) e02368-14; DOI: 10.1128/mBio.02368-14
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