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Guest Editorial

Moratorium on Research Intended To Create Novel Potential Pandemic Pathogens

Marc Lipsitch, Thomas V. Inglesby
Marc Lipsitch
aDepartment of Epidemiology, Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, Massachusetts, USA
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Thomas V. Inglesby
bUPMC Center for Health Security, Baltimore, Maryland, USA
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DOI: 10.1128/mBio.02366-14
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This article has a correction. Please see:

  • Erratum for Lipsitch and Inglesby, Moratorium on Research Intended To Create Novel Potential Pandemic Pathogens - February 10, 2015

The views expressed in this article do not necessarily reflect the views of the journal or of ASM.

EDITORIAL

Research on highly pathogenic organisms is crucial for medicine and public health, and we strongly support it. This work creates a foundation of new knowledge that provides critical insights around the world’s most deadly infectious diseases, and it can lay groundwork for the future development of new diagnostics, medicines, and vaccines. Almost all such research can be performed in ways that pose negligible or no risk of epidemic or global spread of a novel pathogen. However, research that aims to create new potential pandemic pathogens (PPP) (1)—novel microbes that combine likely human virulence with likely efficient transmission in humans—is an exception to that rule. While this research represents a tiny portion of the experimental work done in infectious disease research, it poses extraordinary potential risks to the public.

Experiments that create the possibility of initiating a pandemic should be subject to a rigorous quantitative risk assessment and a search for safer alternatives before they are approved or performed. Yet a rigorous and transparent risk assessment process for this work has not yet been established. This is why we support the recently announced moratorium on funding new “gain-of-function” (GOF) experiments that enhance mammalian transmissibility or virulence in severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and influenza viruses. This realm of work roughly corresponds with the work we have termed PPP above. Because the term “gain of function” in other contexts can be used to describe techniques of scientific research that have nothing to do …

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Moratorium on Research Intended To Create Novel Potential Pandemic Pathogens
Marc Lipsitch, Thomas V. Inglesby
mBio Dec 2014, 5 (6) e02366-14; DOI: 10.1128/mBio.02366-14

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Moratorium on Research Intended To Create Novel Potential Pandemic Pathogens
Marc Lipsitch, Thomas V. Inglesby
mBio Dec 2014, 5 (6) e02366-14; DOI: 10.1128/mBio.02366-14
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    • EDITORIAL
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