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Research Article

Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus

Arancha Hevia, Christian Milani, Patricia López, Adriana Cuervo, Silvia Arboleya, Sabrina Duranti, Francesca Turroni, Sonia González, Ana Suárez, Miguel Gueimonde, Marco Ventura, Borja Sánchez, Abelardo Margolles
Nicola Segata, Invited Editor, Maria Gloria Dominguez Bello, Editor
Arancha Hevia
aInstituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas, Villaviciosa, Asturias, Spain
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Christian Milani
bLaboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy
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Patricia López
cImmunology Area, Department of Functional Biology, University of Oviedo, Asturias, Spain
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Adriana Cuervo
dPhysiology Area, Department of Functional Biology, University of Oviedo, Asturias, Spain
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Silvia Arboleya
aInstituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas, Villaviciosa, Asturias, Spain
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Sabrina Duranti
bLaboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy
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Francesca Turroni
bLaboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy
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Sonia González
dPhysiology Area, Department of Functional Biology, University of Oviedo, Asturias, Spain
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Ana Suárez
cImmunology Area, Department of Functional Biology, University of Oviedo, Asturias, Spain
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Miguel Gueimonde
aInstituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas, Villaviciosa, Asturias, Spain
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Marco Ventura
bLaboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy
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Borja Sánchez
aInstituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas, Villaviciosa, Asturias, Spain
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Abelardo Margolles
aInstituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas, Villaviciosa, Asturias, Spain
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Nicola Segata
University of Trento
Roles: Invited Editor
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Maria Gloria Dominguez Bello
New York University School of Medicine
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DOI: 10.1128/mBio.01548-14
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ABSTRACT

Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease in humans and is characterized by the presence of hyperactive immune cells and aberrant antibody responses to nuclear and cytoplasmic antigens, including characteristic anti–double-stranded DNA antibodies. We performed a cross-sectional study in order to determine if an SLE-associated gut dysbiosis exists in patients without active disease. A group of 20 SLE patients in remission, for which there was strict inclusion and exclusion criteria, was recruited, and we used an optimized Ion Torrent 16S rRNA gene-based analysis protocol to decipher the fecal microbial profiles of these patients and compare them with those of 20 age- and sex-matched healthy control subjects. We found diversity to be comparable based on Shannon’s index. However, we saw a significantly lower Firmicutes/Bacteroidetes ratio in SLE individuals (median ratio, 1.97) than in healthy subjects (median ratio, 4.86; P < 0.002). A lower Firmicutes/Bacteroidetes ratio in SLE individuals was corroborated by quantitative PCR analysis. Notably, a decrease of some Firmicutes families was also detected. This dysbiosis is reflected, based on in silico functional inference, in an overrepresentation of oxidative phosphorylation and glycan utilization pathways in SLE patient microbiota.

IMPORTANCE Growing evidence suggests that the gut microbiota might impact symptoms and progression of some autoimmune diseases. However, how and why this microbial community influences SLE remains to be elucidated. This is the first report describing an SLE-associated intestinal dysbiosis, and it contributes to the understanding of the interplay between the intestinal microbiota and the host in autoimmune disorders.

  • Copyright © 2014 Hevia et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus
Arancha Hevia, Christian Milani, Patricia López, Adriana Cuervo, Silvia Arboleya, Sabrina Duranti, Francesca Turroni, Sonia González, Ana Suárez, Miguel Gueimonde, Marco Ventura, Borja Sánchez, Abelardo Margolles
mBio Sep 2014, 5 (5) e01548-14; DOI: 10.1128/mBio.01548-14

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Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus
Arancha Hevia, Christian Milani, Patricia López, Adriana Cuervo, Silvia Arboleya, Sabrina Duranti, Francesca Turroni, Sonia González, Ana Suárez, Miguel Gueimonde, Marco Ventura, Borja Sánchez, Abelardo Margolles
mBio Sep 2014, 5 (5) e01548-14; DOI: 10.1128/mBio.01548-14
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