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Research Article

The Potent and Broadly Neutralizing Human Dengue Virus-Specific Monoclonal Antibody 1C19 Reveals a Unique Cross-Reactive Epitope on the bc Loop of Domain II of the Envelope Protein

Scott A. Smith, A. Ruklanthi de Alwis, Nurgun Kose, Eva Harris, Kristie D. Ibarra, Kristen M. Kahle, Jennifer M. Pfaff, Xiaoxiao Xiang, Benjamin J. Doranz, Aravinda M. de Silva, S. Kyle Austin, Soila Sukupolvi-Petty, Michael S. Diamond, James E. Crowe, Jr.
W. Ian Lipkin, Editor
Scott A. Smith
Department of Medicine, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USAThe Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA
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A. Ruklanthi de Alwis
Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
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Nurgun Kose
The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA
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Eva Harris
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California, USA
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Kristie D. Ibarra
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California, USA
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Kristen M. Kahle
Integral Molecular Inc., Philadelphia, Pennsylvania, USA
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Jennifer M. Pfaff
Integral Molecular Inc., Philadelphia, Pennsylvania, USA
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Xiaoxiao Xiang
Integral Molecular Inc., Philadelphia, Pennsylvania, USA
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Benjamin J. Doranz
Integral Molecular Inc., Philadelphia, Pennsylvania, USA
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Aravinda M. de Silva
Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
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S. Kyle Austin
Departments of Medicine, Molecular Microbiology, Pathology, and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
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Soila Sukupolvi-Petty
Departments of Medicine, Molecular Microbiology, Pathology, and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
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Michael S. Diamond
Departments of Medicine, Molecular Microbiology, Pathology, and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
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James E. Crowe
The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USADepartment of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USADepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA
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W. Ian Lipkin
Columbia University
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DOI: 10.1128/mBio.00873-13
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Article Information

DOI 
https://doi.org/10.1128/mBio.00873-13
PubMed 
24255124

Published By 
American Society for Microbiology
History 
  • Received October 13, 2013
  • Accepted October 15, 2013
  • Published online November 19, 2013.

Copyright & Usage 
Copyright © 2013 Smith et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
Editors and / or Reviewers 
  • W. Ian Lipkin, Editor, Columbia University

Author Information

  1. Scott A. Smitha,b,
  2. A. Ruklanthi de Alwisc,
  3. Nurgun Koseb,
  4. Eva Harrisd,
  5. Kristie D. Ibarrad,
  6. Kristen M. Kahlee,
  7. Jennifer M. Pfaffe,
  8. Xiaoxiao Xiange,
  9. Benjamin J. Doranze,
  10. Aravinda M. de Silvac,
  11. S. Kyle Austinf,
  12. Soila Sukupolvi-Pettyf,
  13. Michael S. Diamondf,
  14. James E. Crowe, Jr.b,g,h
  1. Department of Medicine, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USAa
  2. The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USAb
  3. Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USAc
  4. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California, USAd
  5. Integral Molecular Inc., Philadelphia, Pennsylvania, USAe
  6. Departments of Medicine, Molecular Microbiology, Pathology, and Immunology, Washington University School of Medicine, St. Louis, Missouri, USAf
  7. Department of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USAg
  8. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USAh
  • Address correspondence to James E. Crowe, Jr., james.crowe{at}vanderbilt.edu.
  • Citation Smith SA, de Alwis AR, Kose N, Harris E, Ibarra KD, Kahle KM, Pfaff JM, Xiang X, Doranz BJ, de Silva AM, Austin SK, Sukupolvi-Petty S, Diamond MS, Crowe JE, Jr. 2013. The potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the envelope protein. mBio 4(6):e00873-13. doi:10.1128/mBio.00873-13.

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The Potent and Broadly Neutralizing Human Dengue Virus-Specific Monoclonal Antibody 1C19 Reveals a Unique Cross-Reactive Epitope on the bc Loop of Domain II of the Envelope Protein
Scott A. Smith, A. Ruklanthi de Alwis, Nurgun Kose, Eva Harris, Kristie D. Ibarra, Kristen M. Kahle, Jennifer M. Pfaff, Xiaoxiao Xiang, Benjamin J. Doranz, Aravinda M. de Silva, S. Kyle Austin, Soila Sukupolvi-Petty, Michael S. Diamond, James E. Crowe Jr.
mBio Nov 2013, 4 (6) e00873-13; DOI: 10.1128/mBio.00873-13

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The Potent and Broadly Neutralizing Human Dengue Virus-Specific Monoclonal Antibody 1C19 Reveals a Unique Cross-Reactive Epitope on the bc Loop of Domain II of the Envelope Protein
Scott A. Smith, A. Ruklanthi de Alwis, Nurgun Kose, Eva Harris, Kristie D. Ibarra, Kristen M. Kahle, Jennifer M. Pfaff, Xiaoxiao Xiang, Benjamin J. Doranz, Aravinda M. de Silva, S. Kyle Austin, Soila Sukupolvi-Petty, Michael S. Diamond, James E. Crowe Jr.
mBio Nov 2013, 4 (6) e00873-13; DOI: 10.1128/mBio.00873-13
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