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Research Article

Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions

Christopher J. Day, Benjamin Bailly, Patrice Guillon, Larissa Dirr, Freda E.-C. Jen, Belinda L. Spillings, Johnson Mak, Mark von Itzstein, Thomas Haselhorst, Michael P. Jennings
James Weger-Lucarelli, Invited Editor, Nisha Duggal, Editor
Christopher J. Day
aInstitute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
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Benjamin Bailly
aInstitute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
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  • ORCID record for Benjamin Bailly
Patrice Guillon
aInstitute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
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Larissa Dirr
aInstitute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
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Freda E.-C. Jen
aInstitute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
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Belinda L. Spillings
aInstitute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
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Johnson Mak
aInstitute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
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Mark von Itzstein
aInstitute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
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Thomas Haselhorst
aInstitute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
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Michael P. Jennings
aInstitute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
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James Weger-Lucarelli
Virginia Tech
Roles: Invited Editor
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Nisha Duggal
Virginia Polytechnic Institute and State University
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DOI: 10.1128/mBio.03681-20
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Article Information

DOI 
https://doi.org/10.1128/mBio.03681-20
PubMed 
33785634

Published By 
American Society for Microbiology
History 
  • Received January 8, 2021
  • Accepted February 25, 2021
  • Published online March 30, 2021.

Copyright & Usage 
Copyright © 2021 Day et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • James Weger-Lucarelli, Invited Editor, Virginia Tech
  • Nisha Duggal, Editor, Virginia Polytechnic Institute and State University

Author Information

  1. Christopher J. Daya,
  2. Benjamin Baillya,
  3. Patrice Guillona,
  4. Larissa Dirra,
  5. Freda E.-C. Jena,
  6. Belinda L. Spillingsa,
  7. Johnson Maka,
  8. Mark von Itzsteina,
  9. Thomas Haselhorsta,
  10. Michael P. Jenningsa
  1. aInstitute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
  • Address correspondence to Thomas Haselhorst, t.haselhorst{at}griffith.edu.au, or Michael P. Jennings, m.jennings{at}griffith.edu.au.
  • Christopher J. Day and Benjamin Bailly contributed equally. Co-first order was determined by chronological contribution to the study.

  • Citation Day CJ, Bailly B, Guillon P, Dirr L, Jen FE-C, Spillings BL, Mak J, von Itzstein M, Haselhorst T, Jennings MP. 2021. Multidisciplinary approaches identify compounds that bind to human ACE2 or SARS-CoV-2 spike protein as candidates to block SARS-CoV-2–ACE2 receptor interactions. mBio 12:e03681-20. https://doi.org/10.1128/mBio.03681-20.

  1. This article is a direct contribution from Michael P. Jennings, a Fellow of the American Academy of Microbiology, who arranged for and secured reviews by Armin Braun, Fraunhofer Institute for Toxicology and Experimental Medicine, and Hui-Ling Yen, University of Hong Kong.

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Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions
Christopher J. Day, Benjamin Bailly, Patrice Guillon, Larissa Dirr, Freda E.-C. Jen, Belinda L. Spillings, Johnson Mak, Mark von Itzstein, Thomas Haselhorst, Michael P. Jennings
mBio Mar 2021, 12 (2) e03681-20; DOI: 10.1128/mBio.03681-20

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Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions
Christopher J. Day, Benjamin Bailly, Patrice Guillon, Larissa Dirr, Freda E.-C. Jen, Belinda L. Spillings, Johnson Mak, Mark von Itzstein, Thomas Haselhorst, Michael P. Jennings
mBio Mar 2021, 12 (2) e03681-20; DOI: 10.1128/mBio.03681-20
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KEYWORDS

ACE2
SARS-CoV-2
drug screening

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