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Research Article

Cryo-EM Structures of CusA Reveal a Mechanism of Metal-Ion Export

Mitchell A. Moseng, Meinan Lyu, Tanadet Pipatpolkai, Przemyslaw Glaza, Corey C. Emerson, Phoebe L. Stewart, Phillip J. Stansfeld, Edward W. Yu
Michael S. Gilmore, Editor
Mitchell A. Moseng
aDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
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Meinan Lyu
aDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
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Tanadet Pipatpolkai
bDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom
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  • ORCID record for Tanadet Pipatpolkai
Przemyslaw Glaza
aDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
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Corey C. Emerson
aDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
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Phoebe L. Stewart
aDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
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  • ORCID record for Phoebe L. Stewart
Phillip J. Stansfeld
cSchool of Life Sciences & Department of Chemistry, University of Warwick, Coventry, United Kingdom
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Edward W. Yu
aDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
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Michael S. Gilmore
Harvard Medical School
Roles: Editor
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DOI: 10.1128/mBio.00452-21
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Article Information

DOI 
https://doi.org/10.1128/mBio.00452-21
PubMed 
33820823

Published By 
American Society for Microbiology
History 
  • Received February 18, 2021
  • Accepted February 25, 2021
  • Published online April 5, 2021.

Copyright & Usage 
Copyright © 2021 Moseng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Michael S. Gilmore, Editor, Harvard Medical School

Author Information

  1. Mitchell A. Mosenga,
  2. Meinan Lyua,
  3. Tanadet Pipatpolkaib,
  4. Przemyslaw Glazaa,
  5. Corey C. Emersona,
  6. Phoebe L. Stewarta,
  7. Phillip J. Stansfeldc,
  8. Edward W. Yua
  1. aDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
  2. bDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom
  3. cSchool of Life Sciences & Department of Chemistry, University of Warwick, Coventry, United Kingdom
  • Address correspondence to Edward W. Yu, edward.w.yu{at}case.edu.
  • Mitchell A. Moseng and Meinan Lyu contributed equally to this work. Author order was determined by drawing straws.

  • Citation Moseng MA, Lyu M, Pipatpolkai T, Glaza P, Emerson CC, Stewart PL, Stansfeld PJ, Yu EW. 2021. Cryo-EM structures of CusA reveal a mechanism of metal-ion export. mBio 12:e00452-21. https://doi.org/10.1128/mBio.00452-21.

  1. This article is a direct contribution from Edward W. Yu, a Fellow of the American Academy of Microbiology, who arranged for and secured reviews by Vassilis Koronakis, University of Cambridge, and Ann Stock, Rutgers University-Robert Wood Johnson Medical School.

Article usage

Article usage: March 2021 to April 2021

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Cryo-EM Structures of CusA Reveal a Mechanism of Metal-Ion Export
Mitchell A. Moseng, Meinan Lyu, Tanadet Pipatpolkai, Przemyslaw Glaza, Corey C. Emerson, Phoebe L. Stewart, Phillip J. Stansfeld, Edward W. Yu
mBio Apr 2021, 12 (2) e00452-21; DOI: 10.1128/mBio.00452-21

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Cryo-EM Structures of CusA Reveal a Mechanism of Metal-Ion Export
Mitchell A. Moseng, Meinan Lyu, Tanadet Pipatpolkai, Przemyslaw Glaza, Corey C. Emerson, Phoebe L. Stewart, Phillip J. Stansfeld, Edward W. Yu
mBio Apr 2021, 12 (2) e00452-21; DOI: 10.1128/mBio.00452-21
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KEYWORDS

CusA
antimicrobial resistance
cryo-EM
efflux pump
resistance-nodulation-cell division

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