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Observation | Therapeutics and Prevention

Tiny Earth: A Big Idea for STEM Education and Antibiotic Discovery

Amanda Hurley, Marc G. Chevrette, Deepa D. Acharya, Gabriel L. Lozano, Manuel Garavito, Jen Heinritz, Luis Balderrama, Mara Beebe, Martel L. DenHartog, Kamiyah Corinaldi, Renee Engels, Alyssa Gutierrez, Orli Jona, Josephine H. I. Putnam, Brody Rhodes, Tiffany Tsang, Simon Hernandez, Carol Bascom-Slack, Jessamina E. Blum, Paul A. Price, Debra Davis, Joanna Klein, Joshua Pultorak, Nora L. Sullivan, Nigel J. Mouncey, Pieter C. Dorrestein, Sarah Miller, Nichole A. Broderick, Jo Handelsman
Joerg Graf, Editor
Amanda Hurley
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Marc G. Chevrette
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Deepa D. Acharya
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Gabriel L. Lozano
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
bDivision of Infectious Diseases and Division of Gastroenterology, Department of Pediatrics, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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Manuel Garavito
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Jen Heinritz
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Luis Balderrama
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
cHamline University, Minneapolis, Minnesota, USA
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Mara Beebe
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Martel L. DenHartog
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Kamiyah Corinaldi
dWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA
eColorado State University, Fort Collins, Colorado, USA
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Renee Engels
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Alyssa Gutierrez
dWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA
fUniversity of Alabama, Tuscaloosa, Alabama, USA
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Orli Jona
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Josephine H. I. Putnam
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Brody Rhodes
dWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA
gUniversity of West Alabama, Livingston, Alabama, USA
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Tiffany Tsang
hDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, USA
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Simon Hernandez
iUniversity of Rochester Medical Center, Rochester, New York, USA
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Carol Bascom-Slack
jDepartment of Medical Education, Tufts University, Boston, Massachusetts, USA
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Jessamina E. Blum
kUniversity of Minnesota Medical School, Minneapolis, Minnesota, USA
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Paul A. Price
lDepartment of Biology, Eastern Michigan University, Ypsilanti, Michigan, USA
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Debra Davis
mDepartment of Biology, Wingate University, Wingate, North Carolina, USA
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Joanna Klein
nDepartment of Biology and Biochemistry, University of Northwestern-St. Paul, Saint Paul, Minnesota, USA
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Joshua Pultorak
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Nora L. Sullivan
oBiology Department, Citrus College, Glendora, California, USA
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Nigel J. Mouncey
pJoint Genome Institute, Berkeley, California, USA
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Pieter C. Dorrestein
qCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA
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Sarah Miller
dWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Nichole A. Broderick
rDepartment of Molecular and Cell Biology, University of Connecticut, Mansfield, Connecticut, USA
sDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA
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Jo Handelsman
aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Joerg Graf
University of Connecticut
Roles: Editor
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DOI: 10.1128/mBio.03432-20
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Article Information

DOI 
https://doi.org/10.1128/mBio.03432-20
PubMed 
33593964

Published By 
American Society for Microbiology
History 
  • Received December 21, 2020
  • Accepted January 4, 2021
  • Published online February 16, 2021.

Copyright & Usage 
Copyright © 2021 Hurley et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Joerg Graf, Editor, University of Connecticut

Author Information

  1. Amanda Hurleya,
  2. Marc G. Chevrettea,
  3. Deepa D. Acharyaa,
  4. Gabriel L. Lozanoa,b,
  5. Manuel Garavitoa,
  6. Jen Heinritza,
  7. Luis Balderramaa,c,
  8. Mara Beebea,
  9. Martel L. DenHartoga,
  10. Kamiyah Corinaldid,e,
  11. Renee Engelsa,
  12. Alyssa Gutierrezd,f,
  13. Orli Jonaa,
  14. Josephine H. I. Putnama,
  15. Brody Rhodesd,g,
  16. Tiffany Tsangh,
  17. Simon Hernandezi,
  18. Carol Bascom-Slackj,
  19. Jessamina E. Blumk,
  20. Paul A. Pricel,
  21. Debra Davism,
  22. Joanna Kleinn,
  23. Joshua Pultoraka,
  24. Nora L. Sullivano,
  25. Nigel J. Mounceyp,
  26. Pieter C. Dorresteinq,
  27. Sarah Millerd,
  28. Nichole A. Broderickr,s,
  29. Jo Handelsmana
  1. aWisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA
  2. bDivision of Infectious Diseases and Division of Gastroenterology, Department of Pediatrics, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
  3. cHamline University, Minneapolis, Minnesota, USA
  4. dWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA
  5. eColorado State University, Fort Collins, Colorado, USA
  6. fUniversity of Alabama, Tuscaloosa, Alabama, USA
  7. gUniversity of West Alabama, Livingston, Alabama, USA
  8. hDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, USA
  9. iUniversity of Rochester Medical Center, Rochester, New York, USA
  10. jDepartment of Medical Education, Tufts University, Boston, Massachusetts, USA
  11. kUniversity of Minnesota Medical School, Minneapolis, Minnesota, USA
  12. lDepartment of Biology, Eastern Michigan University, Ypsilanti, Michigan, USA
  13. mDepartment of Biology, Wingate University, Wingate, North Carolina, USA
  14. nDepartment of Biology and Biochemistry, University of Northwestern-St. Paul, Saint Paul, Minnesota, USA
  15. oBiology Department, Citrus College, Glendora, California, USA
  16. pJoint Genome Institute, Berkeley, California, USA
  17. qCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA
  18. rDepartment of Molecular and Cell Biology, University of Connecticut, Mansfield, Connecticut, USA
  19. sDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA
  • Address correspondence to Nichole A. Broderick, nbroder1{at}jhu.edu, or Jo Handelsman, jo.handelsman{at}wisc.edu.
  • Citation Hurley A, Chevrette MG, Acharya DD, Lozano GL, Garavito M, Heinritz J, Balderrama L, Beebe M, DenHartog ML, Corinaldi K, Engels R, Gutierrez A, Jona O, Putnam JHI, Rhodes B, Tsang T, Hernandez S, Bascom-Slack C, Blum JE, Price PA, Davis D, Klein J, Pultorak J, Sullivan NL, Mouncey NJ, Dorrestein PC, Miller S, Broderick NA, Handelsman J. 2021. Tiny Earth: a big idea for STEM education and antibiotic discovery. mBio 12:e03432-20. https://doi.org/10.1128/mBio.03432-20.

  1. This article is a direct contribution from Jo Handelsman, a Fellow of the American Academy of Microbiology, who arranged for and secured reviews by William Metcalf, University of Illinois at Urbana Champaign, and Margaret McFall-Ngai, University of Hawaii at Manoa.

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Tiny Earth: A Big Idea for STEM Education and Antibiotic Discovery
Amanda Hurley, Marc G. Chevrette, Deepa D. Acharya, Gabriel L. Lozano, Manuel Garavito, Jen Heinritz, Luis Balderrama, Mara Beebe, Martel L. DenHartog, Kamiyah Corinaldi, Renee Engels, Alyssa Gutierrez, Orli Jona, Josephine H. I. Putnam, Brody Rhodes, Tiffany Tsang, Simon Hernandez, Carol Bascom-Slack, Jessamina E. Blum, Paul A. Price, Debra Davis, Joanna Klein, Joshua Pultorak, Nora L. Sullivan, Nigel J. Mouncey, Pieter C. Dorrestein, Sarah Miller, Nichole A. Broderick, Jo Handelsman
mBio Feb 2021, 12 (1) e03432-20; DOI: 10.1128/mBio.03432-20

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Tiny Earth: A Big Idea for STEM Education and Antibiotic Discovery
Amanda Hurley, Marc G. Chevrette, Deepa D. Acharya, Gabriel L. Lozano, Manuel Garavito, Jen Heinritz, Luis Balderrama, Mara Beebe, Martel L. DenHartog, Kamiyah Corinaldi, Renee Engels, Alyssa Gutierrez, Orli Jona, Josephine H. I. Putnam, Brody Rhodes, Tiffany Tsang, Simon Hernandez, Carol Bascom-Slack, Jessamina E. Blum, Paul A. Price, Debra Davis, Joanna Klein, Joshua Pultorak, Nora L. Sullivan, Nigel J. Mouncey, Pieter C. Dorrestein, Sarah Miller, Nichole A. Broderick, Jo Handelsman
mBio Feb 2021, 12 (1) e03432-20; DOI: 10.1128/mBio.03432-20
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KEYWORDS

antimicrobial activity
crowdsourcing
multiomics

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