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Editor's Pick Research Article | Therapeutics and Prevention

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo

Dina A. Moustafa, Ashley W. Wu, Danniel Zamora, Seth M. Daly, Carolyn R. Sturge, Christine Pybus, Bruce L. Geller, Joanna B. Goldberg, David E. Greenberg
Robert A. Bonomo, Editor
Dina A. Moustafa
aDepartment of Pediatrics, Division of Pulmonary, Allergy and Immunology, Cystic Fibrosis, and Sleep, Emory University School of Medicine, Atlanta, Georgia, USA
bEmory+Children’s Center for Cystic Fibrosis and Airway Disease Research, Emory University School of Medicine, Atlanta, Georgia, USA
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  • ORCID record for Dina A. Moustafa
Ashley W. Wu
cDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
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Danniel Zamora
cDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
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Seth M. Daly
cDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
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Carolyn R. Sturge
cDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
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Christine Pybus
cDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
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Bruce L. Geller
dDepartment of Microbiology, Oregon State University, Corvallis, Oregon, USA
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Joanna B. Goldberg
aDepartment of Pediatrics, Division of Pulmonary, Allergy and Immunology, Cystic Fibrosis, and Sleep, Emory University School of Medicine, Atlanta, Georgia, USA
bEmory+Children’s Center for Cystic Fibrosis and Airway Disease Research, Emory University School of Medicine, Atlanta, Georgia, USA
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David E. Greenberg
cDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
eDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
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Robert A. Bonomo
Louis Stokes Veterans Affairs Medical Center
Roles: Editor
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DOI: 10.1128/mBio.02411-20
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Article Information

DOI 
https://doi.org/10.1128/mBio.02411-20
PubMed 
33436433

Published By 
American Society for Microbiology
History 
  • Received August 29, 2020
  • Accepted November 13, 2020
  • Published online January 12, 2021.

Copyright & Usage 
Copyright © 2021 Moustafa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Robert A. Bonomo, Editor, Louis Stokes Veterans Affairs Medical Center

Author Information

  1. Dina A. Moustafaa,b,
  2. Ashley W. Wuc,
  3. Danniel Zamorac*,
  4. Seth M. Dalyc*,
  5. Carolyn R. Sturgec,
  6. Christine Pybusc,
  7. Bruce L. Gellerd,
  8. Joanna B. Goldberga,b,
  9. David E. Greenbergc,e
  1. aDepartment of Pediatrics, Division of Pulmonary, Allergy and Immunology, Cystic Fibrosis, and Sleep, Emory University School of Medicine, Atlanta, Georgia, USA
  2. bEmory+Children’s Center for Cystic Fibrosis and Airway Disease Research, Emory University School of Medicine, Atlanta, Georgia, USA
  3. cDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
  4. dDepartment of Microbiology, Oregon State University, Corvallis, Oregon, USA
  5. eDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
  • Address correspondence to David E. Greenberg, david.greenberg{at}utsouthwestern.edu.
  • ↵* Present address: Danniel Zamora, Department of Medicine, University of Washington, Seattle, Washington, USA; Seth M. Daly, Department of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, New Mexico, USA.

  • Citation Moustafa DA, Wu AW, Zamora D, Daly SM, Sturge CR, Pybus C, Geller BL, Goldberg JB, Greenberg DE. 2021. Peptide-conjugated phosphorodiamidate morpholino oligomers retain activity against multidrug-resistant Pseudomonas aeruginosa in vitro and in vivo. mBio 12:e02411-20. https://doi.org/10.1128/mBio.02411-20.

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Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo
Dina A. Moustafa, Ashley W. Wu, Danniel Zamora, Seth M. Daly, Carolyn R. Sturge, Christine Pybus, Bruce L. Geller, Joanna B. Goldberg, David E. Greenberg
mBio Jan 2021, 12 (1) e02411-20; DOI: 10.1128/mBio.02411-20

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Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo
Dina A. Moustafa, Ashley W. Wu, Danniel Zamora, Seth M. Daly, Carolyn R. Sturge, Christine Pybus, Bruce L. Geller, Joanna B. Goldberg, David E. Greenberg
mBio Jan 2021, 12 (1) e02411-20; DOI: 10.1128/mBio.02411-20
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KEYWORDS

Pseudomonas aeruginosa
antisense
PPMO
experimental therapeutics

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