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Research Article | Host-Microbe Biology

Atypical Ebola Virus Disease in a Nonhuman Primate following Monoclonal Antibody Treatment Is Associated with Glycoprotein Mutations within the Fusion Loop

Logan Banadyga, Wenjun Zhu, Shweta Kailasan, Katie A. Howell, Krzysztof Franaszek, Shihua He, Vinayakumar Siragam, Keding Cheng, Feihu Yan, Estella Moffat, Wenguang Cao, Anders Leung, Carissa Embury-Hyatt, M. Javad Aman, Xiangguo Qiu
Erica Ollmann Saphire, Invited Editor, Michael S. Diamond, Editor
Logan Banadyga
aSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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  • ORCID record for Logan Banadyga
Wenjun Zhu
aSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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Shweta Kailasan
bIntegrated BioTherapeutics, Inc., Rockville, Maryland, USA
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Katie A. Howell
bIntegrated BioTherapeutics, Inc., Rockville, Maryland, USA
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Krzysztof Franaszek
bIntegrated BioTherapeutics, Inc., Rockville, Maryland, USA
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Shihua He
aSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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Vinayakumar Siragam
aSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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Keding Cheng
cScience and Technology Core, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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Feihu Yan
aSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
dKey Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China
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Estella Moffat
eCanadian Food Inspection Agency, National Centre for Foreign and Animal Disease, Winnipeg, Canada
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Wenguang Cao
aSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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Anders Leung
aSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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Carissa Embury-Hyatt
eCanadian Food Inspection Agency, National Centre for Foreign and Animal Disease, Winnipeg, Canada
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M. Javad Aman
bIntegrated BioTherapeutics, Inc., Rockville, Maryland, USA
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Xiangguo Qiu
aSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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Erica Ollmann Saphire
La Jolla Institute for Immunology and The Scripps Research Institute
Roles: Invited Editor
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Michael S. Diamond
Washington University School of Medicine
Roles: Editor
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DOI: 10.1128/mBio.01438-20
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Article Information

DOI 
https://doi.org/10.1128/mBio.01438-20
PubMed 
33436428

Published By 
American Society for Microbiology
History 
  • Received May 29, 2020
  • Accepted November 16, 2020
  • Published online January 12, 2021.

Copyright & Usage 
© Crown copyright 2021. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Erica Ollmann Saphire, Invited Editor, La Jolla Institute for Immunology and The Scripps Research Institute
  • Michael S. Diamond, Editor, Washington University School of Medicine

Author Information

  1. Logan Banadygaa,
  2. Wenjun Zhua,
  3. Shweta Kailasanb,
  4. Katie A. Howellb,
  5. Krzysztof Franaszekb,
  6. Shihua Hea,
  7. Vinayakumar Siragama,
  8. Keding Chengc,
  9. Feihu Yana,d,
  10. Estella Moffate,
  11. Wenguang Caoa,
  12. Anders Leunga,
  13. Carissa Embury-Hyatte,
  14. M. Javad Amanb,
  15. Xiangguo Qiua
  1. aSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
  2. bIntegrated BioTherapeutics, Inc., Rockville, Maryland, USA
  3. cScience and Technology Core, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
  4. dKey Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China
  5. eCanadian Food Inspection Agency, National Centre for Foreign and Animal Disease, Winnipeg, Canada
  • Address correspondence to Logan Banadyga, logan.banadyga{at}canada.ca, M. Javad Aman, jaman{at}integratedbiotherapeutics.com, or Xiangguo Qiu, xiangguo.qiu{at}canada.ca.
  • Citation Banadyga L, Zhu W, Kailasan S, Howell KA, Franaszek K, He S, Siragam V, Cheng K, Yan F, Moffat E, Cao W, Leung A, Embury-Hyatt C, Aman MJ, Qiu X. 2021. Atypical Ebola virus disease in a nonhuman primate following monoclonal antibody treatment is associated with glycoprotein mutations within the fusion loop. mBio 12:e01438-20. https://doi.org/10.1128/mBio.01438-20.

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Atypical Ebola Virus Disease in a Nonhuman Primate following Monoclonal Antibody Treatment Is Associated with Glycoprotein Mutations within the Fusion Loop
Logan Banadyga, Wenjun Zhu, Shweta Kailasan, Katie A. Howell, Krzysztof Franaszek, Shihua He, Vinayakumar Siragam, Keding Cheng, Feihu Yan, Estella Moffat, Wenguang Cao, Anders Leung, Carissa Embury-Hyatt, M. Javad Aman, Xiangguo Qiu
mBio Jan 2021, 12 (1) e01438-20; DOI: 10.1128/mBio.01438-20

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Atypical Ebola Virus Disease in a Nonhuman Primate following Monoclonal Antibody Treatment Is Associated with Glycoprotein Mutations within the Fusion Loop
Logan Banadyga, Wenjun Zhu, Shweta Kailasan, Katie A. Howell, Krzysztof Franaszek, Shihua He, Vinayakumar Siragam, Keding Cheng, Feihu Yan, Estella Moffat, Wenguang Cao, Anders Leung, Carissa Embury-Hyatt, M. Javad Aman, Xiangguo Qiu
mBio Jan 2021, 12 (1) e01438-20; DOI: 10.1128/mBio.01438-20
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KEYWORDS

Ebola virus
Ebola virus disease
filovirus
glycoprotein
monoclonal antibody
pathogenesis
recrudescence

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