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Research Article | Host-Microbe Biology

The TLR3/IRF1/Type III IFN Axis Facilitates Antiviral Responses against Enterovirus Infections in the Intestine

Rui Su, Muhammad Adnan Shereen, Xiaofeng Zeng, Yicong Liang, Wen Li, Zhihui Ruan, Yongkui Li, Weiyong Liu, Yingle Liu, Kailang Wu, Zhen Luo, Jianguo Wu
Nisha Duggal, Editor
Rui Su
aState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
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Muhammad Adnan Shereen
aState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
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Xiaofeng Zeng
cSchool of Forensic Medicine, Kunming Medical University, Kunming, China
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Yicong Liang
bGuangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China
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Wen Li
aState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
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Zhihui Ruan
bGuangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China
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Yongkui Li
bGuangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China
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Weiyong Liu
aState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
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Yingle Liu
aState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
bGuangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China
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Kailang Wu
aState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
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Zhen Luo
bGuangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China
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  • ORCID record for Zhen Luo
Jianguo Wu
aState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
bGuangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China
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Nisha Duggal
Virginia Polytechnic Institute and State University
Roles: Editor
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DOI: 10.1128/mBio.02540-20
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Article Information

DOI 
https://doi.org/10.1128/mBio.02540-20
PubMed 
33203755

Published By 
American Society for Microbiology
History 
  • Received September 9, 2020
  • Accepted October 20, 2020
  • Published online November 17, 2020.

Copyright & Usage 
Copyright © 2020 Su et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Nisha Duggal, Editor, Virginia Polytechnic Institute and State University

Author Information

  1. Rui Sua,
  2. Muhammad Adnan Shereena,
  3. Xiaofeng Zengc,
  4. Yicong Liangb,
  5. Wen Lia,
  6. Zhihui Ruanb,
  7. Yongkui Lib,
  8. Weiyong Liua,
  9. Yingle Liua,b,
  10. Kailang Wua,
  11. Zhen Luob,
  12. Jianguo Wua,b
  1. aState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
  2. bGuangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China
  3. cSchool of Forensic Medicine, Kunming Medical University, Kunming, China
  • Address correspondence to Zhen Luo, zhluo18{at}jnu.edu.cn, or Jianguo Wu, jwu{at}whu.edu.cn.
  • Rui Su, Muhammad Adnan Shereen, and Xiaofeng Zeng contributed equally to this work. Author order was determined in order of increasing seniority.

  • Citation Su R, Shereen MA, Zeng X, Liang Y, Li W, Ruan Z, Li Y, Liu W, Liu Y, Wu K, Luo Z, Wu J. 2020. The TLR3/IRF1/type III IFN axis facilitates antiviral responses against enterovirus infections in the intestine. mBio 11:e02540-20. https://doi.org/10.1128/mBio.02540-20.

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The TLR3/IRF1/Type III IFN Axis Facilitates Antiviral Responses against Enterovirus Infections in the Intestine
Rui Su, Muhammad Adnan Shereen, Xiaofeng Zeng, Yicong Liang, Wen Li, Zhihui Ruan, Yongkui Li, Weiyong Liu, Yingle Liu, Kailang Wu, Zhen Luo, Jianguo Wu
mBio Nov 2020, 11 (6) e02540-20; DOI: 10.1128/mBio.02540-20

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The TLR3/IRF1/Type III IFN Axis Facilitates Antiviral Responses against Enterovirus Infections in the Intestine
Rui Su, Muhammad Adnan Shereen, Xiaofeng Zeng, Yicong Liang, Wen Li, Zhihui Ruan, Yongkui Li, Weiyong Liu, Yingle Liu, Kailang Wu, Zhen Luo, Jianguo Wu
mBio Nov 2020, 11 (6) e02540-20; DOI: 10.1128/mBio.02540-20
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KEYWORDS

enterovirus
type III interferons
intestine epithelial cells
Toll-like receptor 3
interferon regulatory factor 1
coxsackievirus B3
enterovirus 71
intestine
poliovirus 1
enterovirus infection
interferon-stimulated genes
neonatal C57BL/6J mice

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