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Research Article | Host-Microbe Biology

A Small-Molecule Modulator of Metal Homeostasis in Gram-Positive Pathogens

Lillian J. Juttukonda, William N. Beavers, Daisy Unsihuay, Kwangho Kim, Gleb Pishchany, Kyle J. Horning, Andy Weiss, Hassan Al-Tameemi, Jeffrey M. Boyd, Gary A. Sulikowski, Aaron B. Bowman, Eric P. Skaar
Paul Dunman, Editor
Lillian J. Juttukonda
aVanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA
gDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
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William N. Beavers
aVanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA
gDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
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Daisy Unsihuay
aVanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA
gDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
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Kwangho Kim
bChemical Synthesis Core, Vanderbilt University, Nashville, Tennessee, USA
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Gleb Pishchany
cDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
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Kyle J. Horning
dVanderbilt Brain Institute, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
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Andy Weiss
aVanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA
gDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
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Hassan Al-Tameemi
eDepartment of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA
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Jeffrey M. Boyd
eDepartment of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA
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  • ORCID record for Jeffrey M. Boyd
Gary A. Sulikowski
aVanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA
bChemical Synthesis Core, Vanderbilt University, Nashville, Tennessee, USA
fDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA
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Aaron B. Bowman
dVanderbilt Brain Institute, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
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Eric P. Skaar
aVanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA
gDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
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Paul Dunman
University of Rochester
Roles: Editor
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DOI: 10.1128/mBio.02555-20
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Article Information

DOI 
https://doi.org/10.1128/mBio.02555-20
PubMed 
33109764

Published By 
American Society for Microbiology
History 
  • Received September 9, 2020
  • Accepted September 29, 2020
  • Published online October 27, 2020.

Copyright & Usage 
Copyright © 2020 Juttukonda et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Paul Dunman, Editor, University of Rochester

Author Information

  1. Lillian J. Juttukondaa,g*,
  2. William N. Beaversa,g,
  3. Daisy Unsihuaya,g*,
  4. Kwangho Kimb,
  5. Gleb Pishchanyc,
  6. Kyle J. Horningd,
  7. Andy Weissa,g,
  8. Hassan Al-Tameemie,
  9. Jeffrey M. Boyde,
  10. Gary A. Sulikowskia,b,f,
  11. Aaron B. Bowmand*,
  12. Eric P. Skaara,g
  1. aVanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA
  2. bChemical Synthesis Core, Vanderbilt University, Nashville, Tennessee, USA
  3. cDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
  4. dVanderbilt Brain Institute, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
  5. eDepartment of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA
  6. fDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA
  7. gDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
  • Address correspondence to Eric P. Skaar, eric.skaar{at}vumc.org.
  • ↵* Present address: Lillian J. Juttukonda, Boston Combined Residency Program, Boston Children’s Hospital, Boston, Massachusetts, USA; Daisy Unsihuay, Department of Chemistry, Purdue University, West Lafayette, Indiana, USA; Aaron B. Bowman, School of Health Sciences, Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA.

  • Lillian J. Juttukonda and William N. Beavers contributed equally to this work. Author order was determined in order of increasing seniority.

  • Citation Juttukonda LJ, Beavers WN, Unsihuay D, Kim K, Pishchany G, Horning KJ, Weiss A, Al-Tameemi H, Boyd JM, Sulikowski GA, Bowman AB, Skaar EP. 2020. A small-molecule modulator of metal homeostasis in Gram-positive pathogens. mBio 11:e02555-20. https://doi.org/10.1128/mBio.02555-20.

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A Small-Molecule Modulator of Metal Homeostasis in Gram-Positive Pathogens
Lillian J. Juttukonda, William N. Beavers, Daisy Unsihuay, Kwangho Kim, Gleb Pishchany, Kyle J. Horning, Andy Weiss, Hassan Al-Tameemi, Jeffrey M. Boyd, Gary A. Sulikowski, Aaron B. Bowman, Eric P. Skaar
mBio Oct 2020, 11 (5) e02555-20; DOI: 10.1128/mBio.02555-20

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A Small-Molecule Modulator of Metal Homeostasis in Gram-Positive Pathogens
Lillian J. Juttukonda, William N. Beavers, Daisy Unsihuay, Kwangho Kim, Gleb Pishchany, Kyle J. Horning, Andy Weiss, Hassan Al-Tameemi, Jeffrey M. Boyd, Gary A. Sulikowski, Aaron B. Bowman, Eric P. Skaar
mBio Oct 2020, 11 (5) e02555-20; DOI: 10.1128/mBio.02555-20
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KEYWORDS

MRSA
Staphylococcus aureus
antibiotics
cobalt
copper
manganese
metalloregulation

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