Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Latest Articles
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • Topics
    • Applied and Environmental Science
    • Clinical Science and Epidemiology
    • Ecological and Evolutionary Science
    • Host-Microbe Biology
    • Molecular Biology and Physiology
    • Therapeutics and Prevention
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About mBio
    • Editor in Chief
    • Board of Editors
    • AAM Fellows
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
mBio
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Latest Articles
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • Topics
    • Applied and Environmental Science
    • Clinical Science and Epidemiology
    • Ecological and Evolutionary Science
    • Host-Microbe Biology
    • Molecular Biology and Physiology
    • Therapeutics and Prevention
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About mBio
    • Editor in Chief
    • Board of Editors
    • AAM Fellows
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
Research Article | Host-Microbe Biology

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition

Jennifer Deborah Wuerth, Matthias Habjan, Markus Kainulainen, Besim Berisha, Damien Bertheloot, Giulio Superti-Furga, Andreas Pichlmair, Friedemann Weber
Tetsuro Ikegami, Invited Editor, Thomas E. Morrison, Editor
Jennifer Deborah Wuerth
aInstitute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, Giessen, Germany
bInstitute for Virology, Philipps-University Marburg, Marburg, Germany
cInstitute of Innate Immunity, University of Bonn, Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jennifer Deborah Wuerth
Matthias Habjan
dInnate Immunity Laboratory, Max-Planck Institute of Biochemistry, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Markus Kainulainen
bInstitute for Virology, Philipps-University Marburg, Marburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Besim Berisha
aInstitute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, Giessen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Damien Bertheloot
cInstitute of Innate Immunity, University of Bonn, Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Giulio Superti-Furga
eCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
fCenter for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andreas Pichlmair
dInnate Immunity Laboratory, Max-Planck Institute of Biochemistry, Munich, Germany
gInstitute of Virology, Technical University of Munich, School of Medicine, Munich, Germany
hGerman Center for Infection Research (DZIF), partner sites Giessen and Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Friedemann Weber
aInstitute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, Giessen, Germany
bInstitute for Virology, Philipps-University Marburg, Marburg, Germany
hGerman Center for Infection Research (DZIF), partner sites Giessen and Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Friedemann Weber
Tetsuro Ikegami
The University of Texas Medical Branch at Galveston
Roles: Invited Editor
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas E. Morrison
University of Colorado School of Medicine
Roles: Editor
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1128/mBio.00976-20
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1128/mBio.00976-20
PubMed 
32665273

Published By 
American Society for Microbiology
History 
  • Received April 21, 2020
  • Accepted June 11, 2020
  • Published online July 14, 2020.

Copyright & Usage 
Copyright © 2020 Wuerth et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Tetsuro Ikegami, Invited Editor, The University of Texas Medical Branch at Galveston
  • Thomas E. Morrison, Editor, University of Colorado School of Medicine

Author Information

  1. Jennifer Deborah Wuertha,b,c,
  2. Matthias Habjand,
  3. Markus Kainulainenb,
  4. Besim Berishaa,
  5. Damien Berthelootc,
  6. Giulio Superti-Furgae,f,
  7. Andreas Pichlmaird,g,h,
  8. Friedemann Webera,b,h
  1. aInstitute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, Giessen, Germany
  2. bInstitute for Virology, Philipps-University Marburg, Marburg, Germany
  3. cInstitute of Innate Immunity, University of Bonn, Bonn, Germany
  4. dInnate Immunity Laboratory, Max-Planck Institute of Biochemistry, Munich, Germany
  5. eCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
  6. fCenter for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria
  7. gInstitute of Virology, Technical University of Munich, School of Medicine, Munich, Germany
  8. hGerman Center for Infection Research (DZIF), partner sites Giessen and Munich, Germany
  • Address correspondence to Friedemann Weber, friedemann.weber{at}vetmed.uni-giessen.de.
  • Citation Wuerth JD, Habjan M, Kainulainen M, Berisha B, Bertheloot D, Superti-Furga G, Pichlmair A, Weber F. 2020. eIF2B as a target for viral evasion of PKR-mediated translation inhibition. mBio 11:e00976-20. https://doi.org/10.1128/mBio.00976-20.

View Abstract

Article usage

Article usage: July 2020 to January 2021

Rendering graph...
AbstractFullPdf
Jul 202035832222
Aug 20202826295
Sep 2020932874
Oct 2020627657
Nov 2020106727
Dec 2020811348
Jan 202158034
PreviousNext
Back to top
Download PDF
Citation Tools
eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition
Jennifer Deborah Wuerth, Matthias Habjan, Markus Kainulainen, Besim Berisha, Damien Bertheloot, Giulio Superti-Furga, Andreas Pichlmair, Friedemann Weber
mBio Jul 2020, 11 (4) e00976-20; DOI: 10.1128/mBio.00976-20

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Alerts
Sign In to Email Alerts with your Email Address
Email

Thank you for sharing this mBio article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition
(Your Name) has forwarded a page to you from mBio
(Your Name) thought you would be interested in this article in mBio.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition
Jennifer Deborah Wuerth, Matthias Habjan, Markus Kainulainen, Besim Berisha, Damien Bertheloot, Giulio Superti-Furga, Andreas Pichlmair, Friedemann Weber
mBio Jul 2020, 11 (4) e00976-20; DOI: 10.1128/mBio.00976-20
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • RESULTS
    • DISCUSSION
    • MATERIALS AND METHODS
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

PKR
phospho-eIF2α
translation inhibition
integrated stress response
viral PKR antagonist
eIF2B
sandfly fever Sicilian phlebovirus
NSs protein

Related Articles

Cited By...

About

  • About mBio
  • Editor in Chief
  • Board of Editors
  • AAM Fellows
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Author Warranty
  • Article Types
  • Ethics
  • Contact Us

Follow #mBio

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Online ISSN: 2150-7511