Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae

DOI: 10.1128/mBio.03189-19

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^aDepartments of Pharmaceutics and Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA
^bDepartment of Chemistry, University of Florida, Gainesville, Florida, USA
^cUniversidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
^dLaboratório de Pesquisa em Resistência Bacteriana, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
^eDepartment of Chemical Biology and Therapeutics, St Jude Children’s Research Hospital, Memphis, Tennessee, USA
^fDepartment of Molecular Genetics and Microbiology, Emerging Pathogens Institute, College of Medicine, University of Florida, Gainesville, Florida, USA
^gInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria, Australia
^hMedical Service and GRECC, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
ⁱDepartments of Medicine, Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
^jCWRU–Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA
^kSchool of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, South Korea
^lInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA

Address correspondence to Jürgen B. Bulitta, jbulitta{at}cop.ufl.edu.
↵* Present address: Tae Hwan Kim, College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk, South Korea.
Tae Hwan Kim and Xun Tao contributed equally to this article. Author sequence for this work was decided by coin toss.
Citation Kim TH, Tao X, Moya B, Jiao Y, Basso KB, Zhou J, Lang Y, Sutaria DS, Zavascki AP, Barth AL, Reeve SM, Schweizer HP, Deveson Lucas D, Boyce JD, Bonomo RA, Lee RE, Shin BS, Louie A, Drusano GL, Bulitta JB. 2020. Novel cassette assay to quantify the outer membrane permeability of five β-lactams simultaneously in carbapenem-resistant Klebsiella pneumoniae and Enterobacter cloacae. mBio 11:e03189-19. https://doi.org/10.1128/mBio.03189-19.

This article is a direct contribution from George L Drusano, a Fellow of the American Academy of Microbiology, who arranged for and secured reviews by Michael Pucci, Spero Therapeutics (United States); Ramkumar Iyer, Entasis Therapeutics Inc; and Frank Schweizer, University of Manitoba.

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