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Research Article | Molecular Biology and Physiology

Plasmodium yoelii Erythrocyte-Binding-like Protein Modulates Host Cell Membrane Structure, Immunity, and Disease Severity

Yu-chih Peng, Yanwei Qi, Cui Zhang, Xiangyu Yao, Jian Wu, Sittiporn Pattaradilokrat, Lu Xia, Keyla C. Tumas, Xiao He, Takahiro Ishizaki, Chen-Feng Qi, Anthony A. Holder, Timothy G. Myers, Carole A. Long, Osamu Kaneko, Jian Li, Xin-zhuan Su
Stephen L. Hajduk, Editor
Yu-chih Peng
aMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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Yanwei Qi
aMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
bDepartment of Pathogenic Biology and Immunology, Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology, Sino-French Hoffmann Institute, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
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Cui Zhang
aMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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Xiangyu Yao
aMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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Jian Wu
aMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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Sittiporn Pattaradilokrat
aMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
cDepartment of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
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Lu Xia
aMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
dState Key Laboratory of Medical Genetics, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
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Keyla C. Tumas
aMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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Xiao He
aMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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Takahiro Ishizaki
eDepartment of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan
fLeading Program, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
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Chen-Feng Qi
gLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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Anthony A. Holder
hMalaria Parasitology Laboratory, The Francis Crick Institute, London, United Kingdom
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  • ORCID record for Anthony A. Holder
Timothy G. Myers
iGenomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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  • ORCID record for Timothy G. Myers
Carole A. Long
aMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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Osamu Kaneko
eDepartment of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan
fLeading Program, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
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Jian Li
jState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
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Xin-zhuan Su
aMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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Stephen L. Hajduk
University of Georgia
Roles: Editor
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DOI: 10.1128/mBio.02995-19
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Article Information

DOI 
https://doi.org/10.1128/mBio.02995-19
PubMed 
31911494

Published By 
American Society for Microbiology
History 
  • Received November 14, 2019
  • Accepted November 19, 2019
  • Published online January 7, 2020.

Copyright & Usage 
This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply.
Editors and / or Reviewers 
  • Stephen L. Hajduk, Editor, University of Georgia

Author Information

  1. Yu-chih Penga,
  2. Yanwei Qia,b,
  3. Cui Zhanga,
  4. Xiangyu Yaoa,
  5. Jian Wua,
  6. Sittiporn Pattaradilokrata,c,
  7. Lu Xiaa,d,
  8. Keyla C. Tumasa,
  9. Xiao Hea,
  10. Takahiro Ishizakie,f,
  11. Chen-Feng Qig,
  12. Anthony A. Holderh,
  13. Timothy G. Myersi,
  14. Carole A. Longa,
  15. Osamu Kanekoe,f,
  16. Jian Lij,
  17. Xin-zhuan Sua
  1. aMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
  2. bDepartment of Pathogenic Biology and Immunology, Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology, Sino-French Hoffmann Institute, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
  3. cDepartment of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
  4. dState Key Laboratory of Medical Genetics, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
  5. eDepartment of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan
  6. fLeading Program, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
  7. gLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
  8. hMalaria Parasitology Laboratory, The Francis Crick Institute, London, United Kingdom
  9. iGenomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
  10. jState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
  • Address correspondence to Xin-zhuan Su, xsu{at}niaid.nih.gov.
  • Yu-chih Peng and Yanwei Qi contributed approximately equally to this work. Author order was determined by the time spent on the project and in order of increasing seniority.

  • Citation Peng Y-C, Qi Y, Zhang C, Yao X, Wu J, Pattaradilokrat S, Xia L, Tumas KC, He X, Ishizaki T, Qi C-F, Holder AA, Myers TG, Long CA, Kaneko O, Li J, Su X-Z. 2020. Plasmodium yoelii erythrocyte-binding-like protein modulates host cell membrane structure, immunity, and disease severity. mBio 11:e02995-19. https://doi.org/10.1128/mBio.02995-19.

  1. This article is a direct contribution from Xin-zhuan Su, a Fellow of the American Academy of Microbiology, who arranged for and secured reviews by Sanjai Kumar, Food and Drug Administration, and Fidel Zavala, Johns Hopkins University.

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Plasmodium yoelii Erythrocyte-Binding-like Protein Modulates Host Cell Membrane Structure, Immunity, and Disease Severity
Yu-chih Peng, Yanwei Qi, Cui Zhang, Xiangyu Yao, Jian Wu, Sittiporn Pattaradilokrat, Lu Xia, Keyla C. Tumas, Xiao He, Takahiro Ishizaki, Chen-Feng Qi, Anthony A. Holder, Timothy G. Myers, Carole A. Long, Osamu Kaneko, Jian Li, Xin-zhuan Su
mBio Jan 2020, 11 (1) e02995-19; DOI: 10.1128/mBio.02995-19

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Plasmodium yoelii Erythrocyte-Binding-like Protein Modulates Host Cell Membrane Structure, Immunity, and Disease Severity
Yu-chih Peng, Yanwei Qi, Cui Zhang, Xiangyu Yao, Jian Wu, Sittiporn Pattaradilokrat, Lu Xia, Keyla C. Tumas, Xiao He, Takahiro Ishizaki, Chen-Feng Qi, Anthony A. Holder, Timothy G. Myers, Carole A. Long, Osamu Kaneko, Jian Li, Xin-zhuan Su
mBio Jan 2020, 11 (1) e02995-19; DOI: 10.1128/mBio.02995-19
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KEYWORDS

Plasmodium
mouse
erythrocyte-binding-like
EBL
interferon
pathogen-host interaction
phagocytosis

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