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Research Article | Therapeutics and Prevention

Attenuation of Live-Attenuated Yellow Fever 17D Vaccine Virus Is Localized to a High-Fidelity Replication Complex

Emily H. Davis, Andrew S. Beck, Ashley E. Strother, Jill K. Thompson, Steven G. Widen, Stephen Higgs, Thomas G. Wood, Alan D. T. Barrett
Mary K. Estes, Editor
Emily H. Davis
aDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA
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Andrew S. Beck
aDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA
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Ashley E. Strother
aDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA
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Jill K. Thompson
bDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas, USA
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Steven G. Widen
bDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas, USA
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Stephen Higgs
eBiosecurity Research Institute, Kansas State University, Manhattan, Kansas, USA
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Thomas G. Wood
bDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas, USA
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Alan D. T. Barrett
aDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA
cDepartment of Microbiology & Immunology, The University of Texas Medical Branch, Galveston, Texas, USA
dSealy Institute for Vaccine Sciences, The University of Texas Medical Branch, Galveston, Texas, USA
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Mary K. Estes
Baylor College of Medicine
Roles: Editor
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DOI: 10.1128/mBio.02294-19
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Article Information

DOI 
https://doi.org/10.1128/mBio.02294-19
PubMed 
31641088

Published By 
American Society for Microbiology
History 
  • Received September 4, 2019
  • Accepted September 13, 2019
  • Published online October 22, 2019.

Copyright & Usage 
Copyright © 2019 Davis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Mary K. Estes, Editor, Baylor College of Medicine

Author Information

  1. Emily H. Davisa,
  2. Andrew S. Becka*,
  3. Ashley E. Strothera,
  4. Jill K. Thompsonb,
  5. Steven G. Widenb,
  6. Stephen Higgse,
  7. Thomas G. Woodb,
  8. Alan D. T. Barretta,c,d
  1. aDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA
  2. bDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas, USA
  3. cDepartment of Microbiology & Immunology, The University of Texas Medical Branch, Galveston, Texas, USA
  4. dSealy Institute for Vaccine Sciences, The University of Texas Medical Branch, Galveston, Texas, USA
  5. eBiosecurity Research Institute, Kansas State University, Manhattan, Kansas, USA
  • Address correspondence to Alan D. T. Barrett, abarrett{at}utmb.edu.
  • ↵* Present address: Andrew S. Beck, Viral Vaccine Preventable Diseases Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

  • E.H.D. and A.S.B. contributed equally to this work.

  • Citation Davis EH, Beck AS, Strother AE, Thompson JK, Widen SG, Higgs S, Wood TG, Barrett ADT. 2019. Attenuation of live-attenuated yellow fever 17D vaccine virus is localized to a high-fidelity replication complex. mBio 10:e02294-19. https://doi.org/10.1128/mBio.02294-19.

  1. This article is a direct contribution from Alan D. T. Barrett, a Fellow of the American Academy of Microbiology, who arranged for and secured reviews by John Shiver, Sanofi Pasteur Vaccines, and Marshall Bloom, NIAID-NIH.

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Attenuation of Live-Attenuated Yellow Fever 17D Vaccine Virus Is Localized to a High-Fidelity Replication Complex
Emily H. Davis, Andrew S. Beck, Ashley E. Strother, Jill K. Thompson, Steven G. Widen, Stephen Higgs, Thomas G. Wood, Alan D. T. Barrett
mBio Oct 2019, 10 (5) e02294-19; DOI: 10.1128/mBio.02294-19

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Attenuation of Live-Attenuated Yellow Fever 17D Vaccine Virus Is Localized to a High-Fidelity Replication Complex
Emily H. Davis, Andrew S. Beck, Ashley E. Strother, Jill K. Thompson, Steven G. Widen, Stephen Higgs, Thomas G. Wood, Alan D. T. Barrett
mBio Oct 2019, 10 (5) e02294-19; DOI: 10.1128/mBio.02294-19
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KEYWORDS

yellow fever
attenuation
vaccine
ribavirin
quasispecies
live virus vaccine

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