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Research Article | Therapeutics and Prevention

Clonal Confinement of a Highly Mobile Resistance Element Driven by Combination Therapy in Rhodococcus equi

Sonsiray Álvarez-Narváez, Steeve Giguère, Elisa Anastasi, Jack Hearn, Mariela Scortti, José A. Vázquez-Boland
Carmen Buchrieser, Editor
Sonsiray Álvarez-Narváez
aMicrobial Pathogenesis Group, Infection Medicine, Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, United Kingdom
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Steeve Giguère
bDepartment of Large Animal Medicine, University of Georgia, Athens, Georgia, USA
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Elisa Anastasi
aMicrobial Pathogenesis Group, Infection Medicine, Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, United Kingdom
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Jack Hearn
cInstitute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom
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Mariela Scortti
aMicrobial Pathogenesis Group, Infection Medicine, Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, United Kingdom
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José A. Vázquez-Boland
aMicrobial Pathogenesis Group, Infection Medicine, Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, United Kingdom
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Carmen Buchrieser
Institut Pasteur
Roles: Editor
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DOI: 10.1128/mBio.02260-19
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Article Information

DOI 
https://doi.org/10.1128/mBio.02260-19
PubMed 
31615959

Published By 
American Society for Microbiology
History 
  • Received August 27, 2019
  • Accepted September 9, 2019
  • Published online October 15, 2019.

Copyright & Usage 
Copyright © 2019 Álvarez-Narváez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Carmen Buchrieser, Editor, Institut Pasteur

Author Information

  1. Sonsiray Álvarez-Narváeza,
  2. Steeve Giguèreb†,
  3. Elisa Anastasia,
  4. Jack Hearnc,
  5. Mariela Scorttia,
  6. José A. Vázquez-Bolanda
  1. aMicrobial Pathogenesis Group, Infection Medicine, Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, United Kingdom
  2. bDepartment of Large Animal Medicine, University of Georgia, Athens, Georgia, USA
  3. cInstitute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom
  • Address correspondence to José A. Vázquez-Boland, v.boland{at}ed.ac.uk.
  • ↵† Deceased.

  • Citation Álvarez-Narváez S, Giguère S, Anastasi E, Hearn J, Scortti M, Vázquez-Boland JA. 2019. Clonal confinement of a highly mobile resistance element driven by combination therapy in Rhodococcus equi. mBio 10:e02260-19. https://doi.org/10.1128/mBio.02260-19.

  1. This article is a direct contribution from José A. Vázquez-Boland, a Fellow of the American Academy of Microbiology, who arranged for and secured reviews by Gary Muscatello, University of Sydney, and David Horohov, University of Kentucky.

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Clonal Confinement of a Highly Mobile Resistance Element Driven by Combination Therapy in Rhodococcus equi
Sonsiray Álvarez-Narváez, Steeve Giguère, Elisa Anastasi, Jack Hearn, Mariela Scortti, José A. Vázquez-Boland
mBio Oct 2019, 10 (5) e02260-19; DOI: 10.1128/mBio.02260-19

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Clonal Confinement of a Highly Mobile Resistance Element Driven by Combination Therapy in Rhodococcus equi
Sonsiray Álvarez-Narváez, Steeve Giguère, Elisa Anastasi, Jack Hearn, Mariela Scortti, José A. Vázquez-Boland
mBio Oct 2019, 10 (5) e02260-19; DOI: 10.1128/mBio.02260-19
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KEYWORDS

ISRe46
MDR clonality
Rhodococcus equi
Rhodococcus equi MDR clone
Rhodococcus hoagii
Rhodococcus pneumonia
TnRErm46
erm(46)
macrolide resistance
multidrug resistance
pRErm46
rifampin resistance

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