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Research Article | Clinical Science and Epidemiology

Plasmid Dissemination and Selection of a Multidrug-Resistant Klebsiella pneumoniae Strain during Transplant-Associated Antibiotic Therapy

Sean Conlan, Anna F. Lau, Clay Deming, Christine D. Spalding, ShihQueen Lee-Lin, Pamela J. Thomas, Morgan Park, John P. Dekker, Karen M. Frank, Tara N. Palmore, Julia A. Segre
Robert A. Bonomo, Editor
Sean Conlan
aNational Human Genome Research Institute, Bethesda, Maryland, USA
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Anna F. Lau
bNational Institutes of Health Clinical Center, Bethesda, Maryland, USA
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Clay Deming
aNational Human Genome Research Institute, Bethesda, Maryland, USA
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Christine D. Spalding
bNational Institutes of Health Clinical Center, Bethesda, Maryland, USA
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ShihQueen Lee-Lin
aNational Human Genome Research Institute, Bethesda, Maryland, USA
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Pamela J. Thomas
cNational Institutes of Health Intramural Sequencing Center (NISC), Rockville, Maryland, USA
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Morgan Park
cNational Institutes of Health Intramural Sequencing Center (NISC), Rockville, Maryland, USA
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John P. Dekker
bNational Institutes of Health Clinical Center, Bethesda, Maryland, USA
dNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
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Karen M. Frank
bNational Institutes of Health Clinical Center, Bethesda, Maryland, USA
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Tara N. Palmore
bNational Institutes of Health Clinical Center, Bethesda, Maryland, USA
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Julia A. Segre
aNational Human Genome Research Institute, Bethesda, Maryland, USA
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Robert A. Bonomo
Louis Stokes Veterans Affairs Medical Center
Roles: Editor
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DOI: 10.1128/mBio.00652-19
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Article Information

DOI 
https://doi.org/10.1128/mBio.00652-19
PubMed 
31594809

Published By 
American Society for Microbiology
History 
  • Received March 13, 2019
  • Accepted September 3, 2019
  • Published online October 8, 2019.

Copyright & Usage 
Copyright © 2019 Conlan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Robert A. Bonomo, Editor, Louis Stokes Veterans Affairs Medical Center

Author Information

  1. Sean Conlana,
  2. Anna F. Laub,
  3. Clay Deminga,
  4. Christine D. Spaldingb,
  5. ShihQueen Lee-Lina,
  6. Pamela J. Thomasc,
  7. Morgan Parkc,
  8. John P. Dekkerb,d,
  9. Karen M. Frankb,
  10. Tara N. Palmoreb,
  11. Julia A. Segrea
  1. aNational Human Genome Research Institute, Bethesda, Maryland, USA
  2. bNational Institutes of Health Clinical Center, Bethesda, Maryland, USA
  3. cNational Institutes of Health Intramural Sequencing Center (NISC), Rockville, Maryland, USA
  4. dNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
  • Address correspondence to Sean Conlan, conlans{at}mail.nih.gov.
  • Citation Conlan S, Lau AF, Deming C, Spalding CD, Lee-Lin S, Thomas PJ, Park M, Dekker JP, Frank KM, Palmore TN, Segre JA. 2019. Plasmid dissemination and selection of a multidrug-resistant Klebsiella pneumoniae strain during transplant-associated antibiotic therapy. mBio 10:e00652-19. https://doi.org/10.1128/mBio.00652-19.

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Plasmid Dissemination and Selection of a Multidrug-Resistant Klebsiella pneumoniae Strain during Transplant-Associated Antibiotic Therapy
Sean Conlan, Anna F. Lau, Clay Deming, Christine D. Spalding, ShihQueen Lee-Lin, Pamela J. Thomas, Morgan Park, John P. Dekker, Karen M. Frank, Tara N. Palmore, Julia A. Segre
mBio Oct 2019, 10 (5) e00652-19; DOI: 10.1128/mBio.00652-19

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Plasmid Dissemination and Selection of a Multidrug-Resistant Klebsiella pneumoniae Strain during Transplant-Associated Antibiotic Therapy
Sean Conlan, Anna F. Lau, Clay Deming, Christine D. Spalding, ShihQueen Lee-Lin, Pamela J. Thomas, Morgan Park, John P. Dekker, Karen M. Frank, Tara N. Palmore, Julia A. Segre
mBio Oct 2019, 10 (5) e00652-19; DOI: 10.1128/mBio.00652-19
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KEYWORDS

Enterobacteriaceae
HGT
Klebsiella
antibiotic resistance
carbapenems
genomes
plasmids

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