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Editor's Pick Research Article | Host-Microbe Biology

A Protein Antagonist of Activation-Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus

Gurvani B. Singh, Hyewon Byun, Almas F. Ali, Frank Medina, Dennis Wylie, Haridha Shivram, Andrea K. Nash, Mary M. Lozano, Jaquelin P. Dudley
Jaisri R. Lingappa, Editor
Gurvani B. Singh
Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
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Hyewon Byun
Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
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Almas F. Ali
Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
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Frank Medina
Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
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Dennis Wylie
Computational Biology and Bioinformatics and Center for Biomedical Research Support, The University of Texas at Austin, Austin, Texas, USA
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Haridha Shivram
Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
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Andrea K. Nash
Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
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Mary M. Lozano
Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
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Jaquelin P. Dudley
Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
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Jaisri R. Lingappa
University of Washington
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Welkin Johnson
Boston College
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Tatyana Golovkina
University of Chicago
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DOI: 10.1128/mBio.01678-19
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Article Information

DOI 
https://doi.org/10.1128/mBio.01678-19
PubMed 
31409681

Published By 
American Society for Microbiology
History 
  • Received June 26, 2019
  • Accepted July 8, 2019
  • Published online August 13, 2019.

Copyright & Usage 
Copyright © 2019 Singh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Jaisri R. Lingappa, Editor, University of Washington
  • Welkin Johnson, Solicited external reviewer, Boston College
  • Tatyana Golovkina, Solicited external reviewer, University of Chicago

Author Information

  1. Gurvani B. Singha*,
  2. Hyewon Byuna,
  3. Almas F. Alia,
  4. Frank Medinaa,
  5. Dennis Wylieb,
  6. Haridha Shivrama*,
  7. Andrea K. Nasha*,
  8. Mary M. Lozanoa,
  9. Jaquelin P. Dudleya
  1. aDept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
  2. bComputational Biology and Bioinformatics and Center for Biomedical Research Support, The University of Texas at Austin, Austin, Texas, USA
  • Address correspondence to Jaquelin P. Dudley, jdudley{at}austin.utexas.edu.
  • ↵* Present address: Gurvani B. Singh, Cerus Corporation, Concord, CA, USA; Haridha Shivram, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; Andrea K. Nash, Nestlé Purina PetCare Company, St. Louis, MO, USA.

  • Citation Singh GB, Byun H, Ali AF, Medina F, Wylie D, Shivram H, Nash AK, Lozano MM, Dudley JP. 2019. A protein antagonist of activation-induced cytidine deaminase encoded by a complex mouse retrovirus. mBio 10:e01678-19. https://doi.org/10.1128/mBio.01678-19.

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A Protein Antagonist of Activation-Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus
Gurvani B. Singh, Hyewon Byun, Almas F. Ali, Frank Medina, Dennis Wylie, Haridha Shivram, Andrea K. Nash, Mary M. Lozano, Jaquelin P. Dudley
mBio Aug 2019, 10 (4) e01678-19; DOI: 10.1128/mBio.01678-19

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A Protein Antagonist of Activation-Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus
Gurvani B. Singh, Hyewon Byun, Almas F. Ali, Frank Medina, Dennis Wylie, Haridha Shivram, Andrea K. Nash, Mary M. Lozano, Jaquelin P. Dudley
mBio Aug 2019, 10 (4) e01678-19; DOI: 10.1128/mBio.01678-19
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KEYWORDS

AID inhibitor
Apobec3
activation-induced cytidine deaminase
mouse mammary tumor virus
retroviruses

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