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Research Article | Clinical Science and Epidemiology

Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak

Santosh K. Bikkarolla, Viveka Nordberg, Fredrika Rajer, Vilhelm Müller, Muhammad Humaun Kabir, Sriram KK, Albertas Dvirnas, Tobias Ambjörnsson, Christian G. Giske, Lars Navér, Linus Sandegren, Fredrik Westerlund
Spyros Pournaras, Invited Editor, Karen Bush, Editor
Santosh K. Bikkarolla
aDepartment of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
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Viveka Nordberg
bDepartment of Neonatology, Karolinska University Hospital, Stockholm, Sweden
cDepartment of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden
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Fredrika Rajer
dDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
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  • ORCID record for Fredrika Rajer
Vilhelm Müller
aDepartment of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
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Muhammad Humaun Kabir
eDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
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Sriram KK
aDepartment of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
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Albertas Dvirnas
fDepartment of Astronomy and Theoretical Physics, Lund University, Lund, Sweden
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Tobias Ambjörnsson
fDepartment of Astronomy and Theoretical Physics, Lund University, Lund, Sweden
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Christian G. Giske
eDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
gDepartment of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden
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Lars Navér
bDepartment of Neonatology, Karolinska University Hospital, Stockholm, Sweden
cDepartment of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden
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Linus Sandegren
dDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
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Fredrik Westerlund
aDepartment of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
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Spyros Pournaras
Medical School, University of Athens
Roles: Invited Editor
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Karen Bush
Indiana University Bloomington
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DOI: 10.1128/mBio.00347-19
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Article Information

DOI 
https://doi.org/10.1128/mBio.00347-19
PubMed 
31289171

Published By 
American Society for Microbiology
History 
  • Received February 7, 2019
  • Accepted June 7, 2019
  • Published online July 9, 2019.

Copyright & Usage 
Copyright © 2019 Bikkarolla et al. This content is distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Spyros Pournaras, Invited Editor, Medical School, University of Athens
  • Karen Bush, Editor, Indiana University Bloomington

Author Information

  1. Santosh K. Bikkarollaa,
  2. Viveka Nordbergb,c,
  3. Fredrika Rajerd,
  4. Vilhelm Müllera,
  5. Muhammad Humaun Kabire,
  6. Sriram KKa,
  7. Albertas Dvirnasf,
  8. Tobias Ambjörnssonf,
  9. Christian G. Giskee,g,
  10. Lars Navérb,c,
  11. Linus Sandegrend,
  12. Fredrik Westerlunda
  1. aDepartment of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
  2. bDepartment of Neonatology, Karolinska University Hospital, Stockholm, Sweden
  3. cDepartment of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden
  4. dDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
  5. eDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
  6. fDepartment of Astronomy and Theoretical Physics, Lund University, Lund, Sweden
  7. gDepartment of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden
  • Address correspondence to Fredrik Westerlund, fredrikw{at}chalmers.se.
  • Citation Bikkarolla SK, Nordberg V, Rajer F, Müller V, Kabir MH, KK S, Dvirnas A, Ambjörnsson T, Giske CG, Navér L, Sandegren L, Westerlund F. 2019. Optical DNA mapping combined with Cas9-targeted resistance gene identification for rapid tracking of resistance plasmids in a neonatal intensive care unit outbreak. mBio 10:e00347-19. https://doi.org/10.1128/mBio.00347-19.

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Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak
Santosh K. Bikkarolla, Viveka Nordberg, Fredrika Rajer, Vilhelm Müller, Muhammad Humaun Kabir, Sriram KK, Albertas Dvirnas, Tobias Ambjörnsson, Christian G. Giske, Lars Navér, Linus Sandegren, Fredrik Westerlund
mBio Jul 2019, 10 (4) e00347-19; DOI: 10.1128/mBio.00347-19

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Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak
Santosh K. Bikkarolla, Viveka Nordberg, Fredrika Rajer, Vilhelm Müller, Muhammad Humaun Kabir, Sriram KK, Albertas Dvirnas, Tobias Ambjörnsson, Christian G. Giske, Lars Navér, Linus Sandegren, Fredrik Westerlund
mBio Jul 2019, 10 (4) e00347-19; DOI: 10.1128/mBio.00347-19
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KEYWORDS

CRISPR/Cas9
optical DNA mapping
antibiotic resistance
intensive care unit
plasmids

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