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Research Article | Molecular Biology and Physiology

Serine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase

Stine Vang Nielsen, Kathryn Jane Turnbull, Mohammad Roghanian, Rene Bærentsen, Maja Semanjski, Ditlev E. Brodersen, Boris Macek, Kenn Gerdes
Michael T. Laub, Editor
Stine Vang Nielsen
aCentre for Bacterial Stress Response and Persistence, Section for Functional Genomics, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Kathryn Jane Turnbull
aCentre for Bacterial Stress Response and Persistence, Section for Functional Genomics, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Mohammad Roghanian
aCentre for Bacterial Stress Response and Persistence, Section for Functional Genomics, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Rene Bærentsen
bCentre for Bacterial Stress Response and Persistence, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
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Maja Semanjski
cProteome Center Tübingen, Interfaculty Institute for Cell Biology, University of Tübingen, Tübingen, Germany
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Ditlev E. Brodersen
bCentre for Bacterial Stress Response and Persistence, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
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Boris Macek
cProteome Center Tübingen, Interfaculty Institute for Cell Biology, University of Tübingen, Tübingen, Germany
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Kenn Gerdes
aCentre for Bacterial Stress Response and Persistence, Section for Functional Genomics, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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  • ORCID record for Kenn Gerdes
Michael T. Laub
Massachusetts Institute of Technology
Roles: Editor
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Sophie Helaine
Imperial College London
Roles: Solicited external reviewer
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Cecilia Arraiano
Instituto de Tecnologia Quimica e Biologica-Universidade Nova de Lisboa
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DOI: 10.1128/mBio.01138-19
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Article Information

DOI 
https://doi.org/10.1128/mBio.01138-19
PubMed 
31213559

Published By 
American Society for Microbiology
History 
  • Received May 3, 2019
  • Accepted May 11, 2019
  • Published online June 18, 2019.

Copyright & Usage 
Copyright © 2019 Vang Nielsen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Michael T. Laub, Editor, Massachusetts Institute of Technology
  • Sophie Helaine, Solicited external reviewer, Imperial College London
  • Cecilia Arraiano, Solicited external reviewer, Instituto de Tecnologia Quimica e Biologica-Universidade Nova de Lisboa

Author Information

  1. Stine Vang Nielsena,
  2. Kathryn Jane Turnbulla*,
  3. Mohammad Roghaniana*,
  4. Rene Bærentsenb,
  5. Maja Semanjskic,
  6. Ditlev E. Brodersenb,
  7. Boris Macekc,
  8. Kenn Gerdesa
  1. aCentre for Bacterial Stress Response and Persistence, Section for Functional Genomics, Department of Biology, University of Copenhagen, Copenhagen, Denmark
  2. bCentre for Bacterial Stress Response and Persistence, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
  3. cProteome Center Tübingen, Interfaculty Institute for Cell Biology, University of Tübingen, Tübingen, Germany
  • Address correspondence to Kenn Gerdes, kgerdes{at}bio.ku.dk.
  • ↵* Present address: Kathryn Jane Turnbull, Department of Molecular Biology, Umeå University, Umeå, Sweden; Mohammad Roghanian, Department of Molecular Biology, Umeå University, Umeå, Sweden.

  • Citation Vang Nielsen S, Turnbull KJ, Roghanian M, Bærentsen R, Semanjski M, Brodersen DE, Macek B, Gerdes K. 2019. Serine-threonine kinases encoded by split hipA homologs inhibit tryptophanyl-tRNA synthetase. mBio 10:e01138-19. https://doi.org/10.1128/mBio.01138-19.

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Serine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase
Stine Vang Nielsen, Kathryn Jane Turnbull, Mohammad Roghanian, Rene Bærentsen, Maja Semanjski, Ditlev E. Brodersen, Boris Macek, Kenn Gerdes
mBio Jun 2019, 10 (3) e01138-19; DOI: 10.1128/mBio.01138-19

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Serine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase
Stine Vang Nielsen, Kathryn Jane Turnbull, Mohammad Roghanian, Rene Bærentsen, Maja Semanjski, Ditlev E. Brodersen, Boris Macek, Kenn Gerdes
mBio Jun 2019, 10 (3) e01138-19; DOI: 10.1128/mBio.01138-19
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KEYWORDS

persistence
ppGpp
toxin/antitoxin systems
translation
tRNA synthetase

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