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Research Article | Host-Microbe Biology

Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production

Shuai Wang, Ayah El-Fahmawi, David A. Christian, Qun Fang, Enrico Radaelli, Longfei Chen, Megan C. Sullivan, Ana M. Misic, Jodi A. Ellringer, Xing-Quan Zhu, Sebastian E. Winter, Christopher A. Hunter, Daniel P. Beiting
Melissa Bruckner Lodoen, Editor
Shuai Wang
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
cState Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China
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Ayah El-Fahmawi
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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David A. Christian
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Qun Fang
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Enrico Radaelli
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Longfei Chen
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Megan C. Sullivan
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Ana M. Misic
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Jodi A. Ellringer
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Xing-Quan Zhu
cState Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China
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Sebastian E. Winter
bDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
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  • ORCID record for Sebastian E. Winter
Christopher A. Hunter
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Daniel P. Beiting
aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Melissa Bruckner Lodoen
UC Irvine
Roles: Editor
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Eric Denkers
University of New Mexico
Roles: Solicited external reviewer
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Michael Grigg
NIAID, NIH
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DOI: 10.1128/mBio.00935-19
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Article Information

DOI 
https://doi.org/10.1128/mBio.00935-19
PubMed 
31138751

Published By 
American Society for Microbiology
History 
  • Received April 13, 2019
  • Accepted April 24, 2019
  • Published online May 28, 2019.

Copyright & Usage 
Copyright © 2019 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Melissa Bruckner Lodoen, Editor, UC Irvine
  • Eric Denkers, Solicited external reviewer, University of New Mexico
  • Michael Grigg, Solicited external reviewer, NIAID, NIH

Author Information

  1. Shuai Wanga,c,
  2. Ayah El-Fahmawia,
  3. David A. Christiana,
  4. Qun Fanga,
  5. Enrico Radaellia,
  6. Longfei Chena,
  7. Megan C. Sullivana,
  8. Ana M. Misica,
  9. Jodi A. Ellringera,
  10. Xing-Quan Zhuc,
  11. Sebastian E. Winterb,
  12. Christopher A. Huntera,
  13. Daniel P. Beitinga
  1. aDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
  2. bDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
  3. cState Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China
  • Address correspondence to Christopher A. Hunter, chunter{at}vet.upenn.edu, or Daniel P. Beiting, beiting{at}vet.upenn.edu.
  • Citation Wang S, El-Fahmawi A, Christian DA, Fang Q, Radaelli E, Chen L, Sullivan MC, Misic AM, Ellringer JA, Zhu X-Q, Winter SE, Hunter CA, Beiting DP. 2019. Infection-induced intestinal dysbiosis is mediated by macrophage activation and nitrate production. mBio 10:e00935-19. https://doi.org/10.1128/mBio.00935-19.

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Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production
Shuai Wang, Ayah El-Fahmawi, David A. Christian, Qun Fang, Enrico Radaelli, Longfei Chen, Megan C. Sullivan, Ana M. Misic, Jodi A. Ellringer, Xing-Quan Zhu, Sebastian E. Winter, Christopher A. Hunter, Daniel P. Beiting
mBio May 2019, 10 (3) e00935-19; DOI: 10.1128/mBio.00935-19

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Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production
Shuai Wang, Ayah El-Fahmawi, David A. Christian, Qun Fang, Enrico Radaelli, Longfei Chen, Megan C. Sullivan, Ana M. Misic, Jodi A. Ellringer, Xing-Quan Zhu, Sebastian E. Winter, Christopher A. Hunter, Daniel P. Beiting
mBio May 2019, 10 (3) e00935-19; DOI: 10.1128/mBio.00935-19
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KEYWORDS

gut microbiota
microbiome
Toxoplasma
dysbiosis
nitric oxide

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