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Research Article | Host-Microbe Biology

Binding Heterogeneity of Plasmodium falciparum to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1

Maria Bernabeu, Celina Gunnarsson, Maria Vishnyakova, Caitlin C. Howard, Ryan J. Nagao, Marion Avril, Terrie E. Taylor, Karl B. Seydel, Ying Zheng, Joseph D. Smith
L. David Sibley, Editor
Maria Bernabeu
aSeattle Children’s Research Institute, Seattle, Washington, USA
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Celina Gunnarsson
bDepartment of Bioengineering, University of Washington, Seattle, Washington, USA
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Maria Vishnyakova
aSeattle Children’s Research Institute, Seattle, Washington, USA
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Caitlin C. Howard
bDepartment of Bioengineering, University of Washington, Seattle, Washington, USA
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Ryan J. Nagao
bDepartment of Bioengineering, University of Washington, Seattle, Washington, USA
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Marion Avril
aSeattle Children’s Research Institute, Seattle, Washington, USA
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Terrie E. Taylor
cBlantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi
dDepartment of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA
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Karl B. Seydel
cBlantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi
dDepartment of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA
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Ying Zheng
bDepartment of Bioengineering, University of Washington, Seattle, Washington, USA
eCenter for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA
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Joseph D. Smith
aSeattle Children’s Research Institute, Seattle, Washington, USA
fDepartment of Global Health, University of Washington, Seattle, Washington, USA
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L. David Sibley
Washington University School of Medicine
Roles: Editor
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DOI: 10.1128/mBio.00420-19
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Article Information

DOI 
https://doi.org/10.1128/mBio.00420-19
PubMed 
31138740

Published By 
American Society for Microbiology
History 
  • Received February 15, 2019
  • Accepted April 22, 2019
  • Published online May 28, 2019.

Copyright & Usage 
Copyright © 2019 Bernabeu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • L. David Sibley, Editor, Washington University School of Medicine

Author Information

  1. Maria Bernabeua,
  2. Celina Gunnarssonb*,
  3. Maria Vishnyakovaa,
  4. Caitlin C. Howardb,
  5. Ryan J. Nagaob,
  6. Marion Avrila,
  7. Terrie E. Taylorc,d,
  8. Karl B. Seydelc,d,
  9. Ying Zhengb,e,
  10. Joseph D. Smitha,f
  1. aSeattle Children’s Research Institute, Seattle, Washington, USA
  2. bDepartment of Bioengineering, University of Washington, Seattle, Washington, USA
  3. cBlantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi
  4. dDepartment of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA
  5. eCenter for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA
  6. fDepartment of Global Health, University of Washington, Seattle, Washington, USA
  • Address correspondence to Ying Zheng, yingzy{at}uw.edu, or Joseph D. Smith, joe.smith{at}seattlechildrens.org.
  • ↵* Present address: Celina Gunnarsson, Department of Biological Engineering, MIT, Cambridge, Massachusetts, USA.

  • M.B. and C.G. contributed equally to this article.

  • Citation Bernabeu M, Gunnarsson C, Vishnyakova M, Howard CC, Nagao RJ, Avril M, Taylor TE, Seydel KB, Zheng Y, Smith JD. 2019. Binding heterogeneity of Plasmodium falciparum to engineered 3D brain microvessels is mediated by EPCR and ICAM-1. mBio 10:e00420-19. https://doi.org/10.1128/mBio.00420-19.

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Binding Heterogeneity of Plasmodium falciparum to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1
Maria Bernabeu, Celina Gunnarsson, Maria Vishnyakova, Caitlin C. Howard, Ryan J. Nagao, Marion Avril, Terrie E. Taylor, Karl B. Seydel, Ying Zheng, Joseph D. Smith
mBio May 2019, 10 (3) e00420-19; DOI: 10.1128/mBio.00420-19

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Binding Heterogeneity of Plasmodium falciparum to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1
Maria Bernabeu, Celina Gunnarsson, Maria Vishnyakova, Caitlin C. Howard, Ryan J. Nagao, Marion Avril, Terrie E. Taylor, Karl B. Seydel, Ying Zheng, Joseph D. Smith
mBio May 2019, 10 (3) e00420-19; DOI: 10.1128/mBio.00420-19
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KEYWORDS

PfEMP1
Plasmodium falciparum
cerebral malaria
microvessels
tissue engineering

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