Host-Microbe Biology
Research Article | Host-Microbe BiologyPotent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5The Nef protein of HIV-1 and the unrelated glycoGag protein of a murine leukemia virus similarly prevent the uptake of antiviral host proteins called SERINC3 and SERINC5 into HIV-1 particles, which enhances their infectiousness. We now show that although both SERINC antagonists can in principle similarly enhance HIV-1 replication, glycoGag is unable to substitute for Nef in primary human cells and in a T cell line called MOLT-3. In MOLT...
Research Article | Host-Microbe BiologyOrigins of Enterovirus Replication Organelles Established by Whole-Cell Electron MicroscopyEnteroviruses are causative agents of a range of human diseases. The replication of these viruses within cells relies on specialized membranous structures termed replication organelles (ROs) that form during infection but whose origin remains elusive. To capture the emergence of enterovirus ROs, we use correlative light and serial block-face scanning electron microscopy, a powerful method to pinpoint rare events in their whole-cell...
Observation | Host-Microbe BiologyIs Anopheles gambiae a Natural Host of Wolbachia?Anopheles gambiae mosquitos are the main vectors of malaria, threatening around half of the world’s population. The bacterial symbiont Wolbachia can interfere with disease transmission by other important insect vectors, but until recently, it was thought to be absent from natural A. gambiae populations. Here, we critically analyze the genomic,...
Letter to the Editor | Host-Microbe BiologyComposite Metagenome-Assembled Genomes Reduce the Quality of Public Genome Repositories
Observation | Host-Microbe BiologyCorrelation between Disease Severity and the Intestinal Microbiome in Mycobacterium tuberculosis-Infected Rhesus MacaquesWhy some but not all individuals infected with Mycobacterium tuberculosis develop disease is poorly understood. Previous studies have revealed an important influence of the microbiota on host resistance to infection with a number of different disease agents. Here, we investigated the possible role of the individual’s microbiome in impacting the outcome of...
Research Article | Host-Microbe BiologyUncoupling the Threading and Unfoldase Actions of Plasmodium HSP101 Reveals Differences in Export between Soluble and Insoluble ProteinsThe Plasmodium parasites that cause malaria export hundreds of proteins into their host red blood cell (RBC). These exported proteins drastically alter the structural and functional properties of the RBC and play critical roles in parasite virulence and survival. To access the RBC cytoplasm, parasite proteins must pass through the Plasmodium translocon of exported proteins (PTEX) located at the membrane interfacing the...
Research Article | Host-Microbe BiologyAntibody Treatment against Angiopoietin-Like 4 Reduces Pulmonary Edema and Injury in Secondary Pneumococcal PneumoniaDespite extensive global efforts, secondary bacterial pneumonia still represents a major cause of death in developing countries and is an important cause of long-term functional disability arising from lung tissue damage. Newer approaches to improving treatment outcomes are needed to reduce the significant morbidity and mortality caused by infectious diseases. Our study, using an experimental mouse model of secondary...
Editor's Pick Research Article | Host-Microbe BiologyCandida albicans Augments Staphylococcus aureus Virulence by Engaging the Staphylococcal agr Quorum Sensing SystemRelatively little is known about the complex interactions and signaling events that occur between microbes and even less so about how microbial “cross talk” shapes human health and disease. Candida albicans (a fungus) and Staphylococcus aureus (a bacterium) are formidable human nosocomial pathogens...
Minireview | Host-Microbe BiologyBenefits and Costs of Animal Virulence for MicrobesThis essay is written from the vantage point of the microbial world. While the focus of much thought in the microbial pathogenesis and infectious diseases fields has been on the impact of host-microbe interaction on the host, here we ask questions about what happens to the microbe.
Opinion/Hypothesis | Host-Microbe BiologyIs the Potable Water System an Advantageous Preinfection Niche for Bacteria Colonizing the Cystic Fibrosis Lung?People with cystic fibrosis are susceptible to lung infections from a variety of bacteria, a number of which also reside in the potable water system, including Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Achromobacter...