Host-Microbe Biology
Research Article | Host-Microbe BiologyA Novel Trichomonas vaginalis Surface Protein Modulates Parasite Attachment via Protein:Host Cell Proteoglycan InteractionThe ability of the sexually transmitted parasite Trichomonas vaginalis to adhere to its human host is critical for establishing and maintaining an infection. Yet how parasites adhere to host cells is poorly understood.
Commentary | Host-Microbe BiologyThe Long and Winding Road for Symbiont and Yolk Protein to Host OocyteMany insects are intimately associated with microbial symbionts, which are passed to developing oocytes in the maternal body for ensuring vertical transmission to the next generation. Previous studies uncovered that some symbionts utilize preexisting host’s molecular and cellular machineries for targeting oocytes.
Research Article | Host-Microbe BiologyPartial Prion Cross-Seeding between Fungal and Mammalian Amyloid Signaling MotifsAmyloids are β-sheet-rich protein polymers that can be pathological or display a variety of biological roles. In filamentous fungi, specific immune receptors activate programmed cell death execution proteins through a process of amyloid templating akin to prion propagation.
Research Article | Host-Microbe BiologyHBV Core Protein Is in Flux between Cytoplasmic, Nuclear, and Nucleolar CompartmentsHBV is an endemic virus. More than 250 million people suffer from chronic HBV infection and about 800,000 die from HBV-associated disease each year.
Editor's Pick Research Article | Host-Microbe BiologyAn Indispensable Role for the MavE Effector of Legionella pneumophila in Lysosomal EvasionIntracellular proliferation of Legionella pneumophila within a vacuole in human alveolar macrophages is essential for manifestation of Legionnaires’ pneumonia. Intravacuolar growth of the pathogen is totally dependent on remodeling the L. pneumophila-containing vacuole (LCV) by the ER and on its...
Research Article | Host-Microbe BiologyDistinct Roles of Two DNA Methyltransferases from Cryphonectria parasitica in Fungal Virulence, Responses to Hypovirus Infection, and Viral ClearanceAlthough relatively few in number, studies of DNA methylation have shown that fungal DNA methylation is implicated in development, genome integrity, and genome defense. While fungal DNMTase has been suggested as playing a role in genome defense, studies of the biological function of fungal DNMTase have been very limited.
Research Article | Host-Microbe BiologyHerpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage ResponsesWe investigated the relationship between the DNA damage response, a collection of vital cellular pathways that repair potentially lethal damage to the genome, and the DNA virus herpes simplex virus 1. We found that infection by the virus triggers the DNA damage response and key proteins that mediate this response have opposing effects on the replication and production of progeny viruses.
Research Article | Host-Microbe BiologyViral Interactions and Pathogenesis during Multiple Viral Infections in Agaricus bisporusHow viruses interact in a multiple-virus infection was examined by quantifying the levels of 18 viral RNAs in fruiting cultures of the agriculturally cultivated fungus Agaricus bisporus and statistically analyzing and modeling their abundance. Synergistic, antagonistic, and neutral interactions occurred simultaneously in cultures.
Research Article | Host-Microbe BiologyRole of Two Metacaspases in Development and Pathogenicity of the Rice Blast Fungus Magnaporthe oryzaeMagnaporthe oryzae causes rice blast disease that threatens global food security by resulting in the severe loss of rice production every year. A tightly regulated life cycle allows M. oryzae to disarm the host plant immune system during its biotrophic stage before triggering plant cell death in its necrotrophic stage.
Research Article | Host-Microbe BiologyHemozoin Promotes Lung Inflammation via Host Epithelial ActivationRespiratory distress (RD) is a complication of severe malaria associated with a particularly high risk for death in African children infected with the parasite Plasmodium falciparum. The pathophysiology underlying RD remains poorly understood, and the condition is managed supportively.