ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection
- Antimicrobial Research Centre, Astbury Centre for Structural Molecular Biology and School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom
- Address correspondence to Alex J. O’Neill, a.j.oneill{at}leeds.ac.uk.
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Editor Gerard D. Wright, McMaster University
IMPORTANCE
Antimicrobial resistance ranks among the greatest threats currently facing human health. Elucidation of the mechanisms by which microorganisms resist the effect of antibiotics is central to understanding the biology of this phenomenon and has the potential to inform the development of new drugs capable of blocking or circumventing resistance. Members of the ABC-F family, which include lsa(A), msr(A), optr(A), and vga(A), collectively yield resistance to a broader range of clinically significant antibiotic classes than any other family of resistance determinants, although their mechanism of action has been controversial since their discovery 25 years ago. Here we present the first direct evidence that proteins of the ABC-F family act to protect the bacterial ribosome from antibiotic-mediated inhibition.
Footnotes
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Citation Sharkey LKR, Edwards TA, O’Neill AJ. 2016. ABC-F proteins mediate antibiotic resistance through ribosomal protection. mBio 7(2):e01975-15. doi:10.1128/mBio.01975-15.
- Received 11 November 2015
- Accepted 5 February 2016
- Published 22 March 2016
- Copyright © 2016 Sharkey et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
