Regulatory Tasks of the Phosphoenolpyruvate-Phosphotransferase System of Pseudomonas putida in Central Carbon Metabolism
- Systems Biology Program, Centro Nacional de Biotecnología (CNB-CSIC), Cantoblanco-Madrid, Spain,a and
- Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerlandb
- Address correspondence to: Víctor de Lorenzo, vdlorenzo{at}cnb.csic.es.
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Editor E. Peter Greenberg, University of Washington
IMPORTANCE
This study demonstrates that EIIANtr influences the biochemical reactions that deliver carbon between the upper and lower central metabolic domains for the consumption of sugars by P. putida. These findings indicate that the EIIANtr protein is a key player for orchestrating the fate of carbon in various physiological destinations in this bacterium. Additionally, these results highlight the importance of the posttranslational regulation of extant enzymatic complexes for increasing the robustness of the corresponding metabolic networks.
Footnotes
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↵* Present address: Fachgebiet Systembiotechnologie, Technische Universität München, Munich, Germany.
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Citation Chavarría M, Kleijn RJ, Sauer U, Pflüger-Grau K, and de Lorenzo V. 2012. Regulatory tasks of the phosphoenolpyruvate-phosphotransferase system of Pseudomonas putida in central carbon metabolism. mBio 3(2):e00028-12. doi:10.1128/mBio.00028-12.
- Received 29 January 2012
- Accepted 2 February 2012
- Published 20 March 2012
- Copyright © 2012 Chavarría et al.
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